1H-Pyrrole-3,4-dicarboxylic acid, 1,2,5-triphenyl-, diethyl ester

Base Information

• Chemical Name: 1H-Pyrrole-3,4-dicarboxylic acid, 1,2,5-triphenyl-, diethyl ester
• CAS No.: 13315-77-0
• Molecular Formula: C28H25NO4
• Molecular Weight: 439.511
• Mol file: 13315-77-0.mol

Synonyms:

Chemical Property of 1H-Pyrrole-3,4-dicarboxylic acid, 1,2,5-triphenyl-, diethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-3,4-dicarboxylic acid, 1,2,5-triphenyl-, diethyl ester

There total 5 articles about 1H-Pyrrole-3,4-dicarboxylic acid, 1,2,5-triphenyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

ethyl (2Z)-3-phenyl-3-(phenylamino)prop-2-enoate (3556-76-1,124413-92-9,53256-22-7) → 3,4-diethoxycarbonyl-1,2,5-triphenylpyrrole (13315-77-0)

Guidance literature:

With ammonium cerium(IV) nitrate; sodium hydrogencarbonate; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2003.12.035

Reference yield: 43.0%

ethyl β-anilinocinnamate (53256-22-7,124413-92-9,3556-76-1) → 3,4-diethoxycarbonyl-1,2,5-triphenylpyrrole (13315-77-0)

Guidance literature:

With sodium acetate; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 20 ℃; for 10h; Inert atmosphere; Electrochemical reaction;

DOI:10.1002/ejoc.202001484

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 3,4-diethoxycarbonyl-1,2,5-triphenylpyrrole (13315-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / 80 °C

2: sodium acetate; tert-butylammonium hexafluorophosphate(V) / acetonitrile / 10 h / 20 °C / Inert atmosphere; Electrochemical reaction

With sodium acetate; tert-butylammonium hexafluorophosphate(V); acetic acid; In methanol; acetonitrile;

DOI:10.1002/ejoc.202001484

upstream raw materials:

ethyl (2Z)-3-phenyl-3-(phenylamino)prop-2-enoate

ethyl β-anilinocinnamate

ethyl 3-oxo-3-phenylpropionate

acetophenone