1,2-Dihydro-1,5-diphenyl-3H-pyrazol-3-one

Base Information

• Chemical Name: 1,2-Dihydro-1,5-diphenyl-3H-pyrazol-3-one
• CAS No.: 13370-06-4
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Hs Code.: 2933199090
• Mol file: 13370-06-4.mol

Synonyms:.1,5-diphenyl-1,2-dihydro-pyrazol-3-one;.1,5-Diphenyl-1,2-dihydro-pyrazol-3-on;.1,5-diphenylpyrazolone-3;.1,5-Diphenyl-4-pyrazolin-3-on;.1.5-Diphenyl-pyrazolon-(3);1,5-diphenylpyrazolin-3-one;

Chemical Property of 1,2-Dihydro-1,5-diphenyl-3H-pyrazol-3-one

Chemical Property:

• Melting Point: 255-256 °C
• PKA: 7.65±0.70(Predicted)
• PSA: 37.79000
• Density: 1.230±0.06 g/cm3(Predicted)
• LogP: 2.83260

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Dihydro-1,5-diphenyl-3H-pyrazol-3-one

There total 27 articles about 1,2-Dihydro-1,5-diphenyl-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,5-diphenylpyrazolidin-3-one (6118-95-2) → 1,5-diphenyl-3-hydroxy-1H-pyrazole (13370-06-4)

Guidance literature:

With iron(III) chloride; oxygen; In N,N-dimethyl-formamide; at 30 - 80 ℃;

DOI:10.1002/jhet.424

Reference yield: 81.0%

ethyl 3-ethoxy-1,5-diphenyl-1H-pyrazole-4-carboxylate (1207432-09-4) → 1,5-diphenyl-4-pyrazolin-3-one (13370-06-4)

Guidance literature:

With hydrogen bromide; acetic acid; at 140 ℃; for 5h; Inert atmosphere;

DOI:10.1002/chem.200903442

Reference yield: 76.87%

4-benzylidene-1-phenyl-3,5-pyrazolidinedione (15083-26-8) → 1,5-diphenyl-4-pyrazolin-3-one (13370-06-4)

Guidance literature:

With chromium(VI) oxide; acetic acid; In water; for 4h; Heating;

DOI:10.1007/s10593-007-0174-y

upstream raw materials:

4-hydroxy-1,5-diphenyl-pyrazolidin-3-one

(E)-3-Ureido-but-2-enoic acid ethyl ester

ethyl 3-oxo-3-phenylpropionate

1-acetyl-2-phenylhydrazine

Downstream raw materials:

1,5-diphenyl-1H-pyrazole

ethyl 2-(4-chloro-1,5-diphenyl-1H-pyrazol-3-yloxy)acetate

2-(4-chloro-1,5-diphenyl-1H-pyrazol-3-yloxy)acetic acid

4-chloro-1,5-diphenyl-1H-pyrazol-3-ol

Refernces

• 1、 Capua, Martina,Granito, Catia,Perrone, Serena,Salomone, Antonio,Troisi, Luigino. "Palladium-catalyzed carbonylative coupling of α-chloroketones with hydrazines: a simple route to pyrazolone derivatives". . p. 3363 - 3367. Retrieved 2016/07/11.
• 2、 Liu, Yuanyuan,He, Guangke,Chen, Kai,Jin, Yin,Li, Yufeng,Zhu, Hongjun. "DMF-catalyzed direct and regioselective C-H functionalization: Electrophilic/nucleophilic 4-halogenation of 3-oxypyrazoles". supporting information; experimental part. p. 5323 - 5330. Retrieved 2011/11/13.