Technology Process of 4-chloro-1,5-diphenyl-1H-pyrazol-3-ol
There total 4 articles about 4-chloro-1,5-diphenyl-1H-pyrazol-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride; N,N-dimethyl-formamide;
for 4h;
regioselective reaction;
Reflux;
DOI:10.1002/ejoc.201100571
- Guidance literature:
-
Multi-step reaction with 2 steps
1: iron(III) chloride hexahydrate; oxygen / N,N-dimethyl-formamide / 22 h / 30 - 80 °C
2: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux
With
thionyl chloride; iron(III) chloride hexahydrate; oxygen; N,N-dimethyl-formamide;
In
N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100571
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium methylate; ethanolamine / butan-1-ol / 0.67 h / Reflux
1.2: 8 h / Reflux
2.1: iron(III) chloride hexahydrate; oxygen / N,N-dimethyl-formamide / 22 h / 30 - 80 °C
3.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux
With
thionyl chloride; iron(III) chloride hexahydrate; oxygen; sodium methylate; ethanolamine; N,N-dimethyl-formamide;
In
N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1002/ejoc.201100571
