Benzenamine, 4-fluoro-N-(2-furanylmethylene)-

Base Information

• Chemical Name: Benzenamine, 4-fluoro-N-(2-furanylmethylene)-
• CAS No.: 13533-21-6
• Molecular Formula: C11H8FNO
• Molecular Weight: 189.189
• DSSTox Substance ID: DTXSID60359389
• Mol file: 13533-21-6.mol

Synonyms:13533-21-6;4-Fluoro-N-(furan-2-ylmethylene)aniline;Benzenamine, 4-fluoro-N-(2-furanylmethylene)-;DTXSID60359389;AKOS027461267

Chemical Property of Benzenamine, 4-fluoro-N-(2-furanylmethylene)-

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 189.058992041
• Heavy Atom Count: 14
• Complexity: 200

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C=NC2=CC=C(C=C2)F

Technology Process of Benzenamine, 4-fluoro-N-(2-furanylmethylene)-

There total 1 articles about Benzenamine, 4-fluoro-N-(2-furanylmethylene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

furfural (98-01-1) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-1-(furan-2-yl)methanimine (13533-21-6)

Guidance literature:

With magnesium sulfate; toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.202000249

Reference yield: 28.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + N-(4-fluorophenyl)-1-(furan-2-yl)methanimine (13533-21-6) → (3aSR,4SR,9bSR)-8-fluoro-4-(2'-furyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline (1062584-14-8)

Guidance literature:

With boron trifluoride diethyl etherate; In benzene; at 0 - 20 ℃; for 5h;

DOI:10.1007/s11172-007-0159-0

Reference yield:

N-(4-fluorophenyl)-1-(furan-2-yl)methanimine (13533-21-6) + acetophenone (98-86-2) → 6-fluoro-2-furan-2-yl-4-phenylquinoline

Guidance literature:

With trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; In toluene; at 120 ℃; for 12h;

DOI:10.1016/j.tetlet.2015.12.028

upstream raw materials:

furfural

4-fluoroaniline

Downstream raw materials:

(3aSR,4SR,9bSR)-8-fluoro-4-(2'-furyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline