1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 4620-34-2
• Molecular Formula: C12H15 N O2
• Molecular Weight: 205.257
• Hs Code.: 2933499090
• Mol file: 4620-34-2.mol

Synonyms:Quinaldicacid, 1,2,3,4-tetrahydro-, ethyl ester (7CI,8CI);1,2,3,4-Tetrahydroquinolin-2-carboxylic acid ethyl ester; Ethyl1,2,3,4-tetrahydro-2-quinolinecarboxylate

Chemical Property of 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000182mmHg at 25°C
• Boiling Point: 329.1°Cat760mmHg
• PKA: 3.20±0.40(Predicted)
• Flash Point: 152.8°C
• PSA: 38.33000
• Density: 1.101g/cm³
• LogP: 2.11440
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl1,2,3,4-Tetrahydroquinoline-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER

There total 4 articles about 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,2,3,4-tetrahydroquinoline-2-carboxylic acid (46185-24-4) + ethanol (64-17-5) → ethyl 1,2,3,4-tetrahydroquinoline-2-carboxylate (4620-34-2)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; at 120 ℃; for 0.583333h;

DOI:10.1007/BF00475570

Reference yield:

ethyl quinoline-2-carboxylate (4491-33-2) → ethyl 1,2,3,4-tetrahydroquinoline-2-carboxylate (4620-34-2)

Guidance literature:

ethyl quinoline-2-carboxylate; With hydrogen; acetic acid; 5%-palladium/activated carbon; at 20 ℃; for 2h; under 3102.97 Torr; glass reactor sealed;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

quinoline-2-carboxylic acid (93-10-7,1199266-78-8) → ethyl 1,2,3,4-tetrahydroquinoline-2-carboxylate (4620-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Raney alloy/10percent NaOH / 1 h / 20 °C

2: 82 percent / H₂O₂/H₂SO₄ / 0.58 h / 120 °C

With sodium hydroxide; sulfuric acid; dihydrogen peroxide; nickel;

DOI:10.1007/BF00475570

upstream raw materials:

1,2,3,4-tetrahydroquinoline-2-carboxylic acid

ethanol

quinoline-2-carboxylic acid

ethyl quinoline-2-carboxylate

Downstream raw materials:

Ethyl 1-benzyl-1,2,3,4-tetrahydroquinoline-2-carboxylate

tert-butyl 2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-acetate

2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)-methoxy)acetic acid

[1-(3,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl]-methanol

Refernces

• 1、 -. "ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF". Page/Page column 32. . Retrieved 2008/12/06.
• 2、 Gracheva, I. N.,Tochilkin, A. I.. "Reduction of Quinolinecarboxylic Acids by Raney Alloy". . p. 65 - 67. Retrieved 2007/10/02.