4491-33-2Relevant academic research and scientific papers
HOMOLYTIC ALKOXYCARBONYLATION REACTIONS IN TWO-PHASE SYSTEMS, PART II. STUDIES ON THE ETHOXYCARBONYLATION OF SOME SELECTED ?-DEFICIENT N-HETEROAROMATIC SYSTEMS
Heinisch, Gottfried,Loetsch, Gerhard
, p. 5973 - 5977 (2007/10/02)
A systematic study on the homolytic substitution of pyridine, quinoline and pyrazine by ethoxycarbonyl radicals was performed.It is demonstrated that under appropriate conditions Minisci-type alkoxycarbonylation reactions can provide convenient access to heteroaromatic monocarboxylic acid esters, like alkyl 2-pyrazinecarboxylates and alkyl 4-alkyl-2-pyridinecarboxylates.
Electrochemical Carboxylation of Some Heteroaromatic Compounds
Fuchs, Peter,Hess, Ulrich,Holst, Hans Henrik,Lund, Henning
, p. 185 - 192 (2007/10/02)
Thirty heteroaromatic compounds have been investigated by cyclic voltammetry (CV) and/or preparative scale electrolysis (PSE) in the absence and presence of carbon dioxide.The rate constants of dehalogenation of the primarily formed anion radical of halogenated heterocycles were estimated from cyclic voltammetric data; these data indicated that carboxylation without loss of chlorine is possible under cyclic voltammetric conditions when the rate constant of cleavage is less than about 104 s-1.PSE confirmed that such halogenated heterocycles may be reductively carboxylated without loss of halogen.In the competition between cleavage and carboxylation low temperatures favour the latter reaction.
