2-(2-CHLORO-5-THENOYL)BENZOIC ACID

Base Information

• Chemical Name: 2-(2-CHLORO-5-THENOYL)BENZOIC ACID
• CAS No.: 136309-62-1
• Molecular Formula: C12H7ClO3S
• Molecular Weight: 266.705
• Mol file: 136309-62-1.mol

Synonyms:2-(5-Chlor-thiophen-2-carbonyl)-benzoesaeure;2-(5-chloro-thiophene-2-carbonyl)-benzoic acid;

Chemical Property of 2-(2-CHLORO-5-THENOYL)BENZOIC ACID

Chemical Property:

• Melting Point: 107 - 109 °C (hexane)
• PSA: 82.61000
• LogP: 3.33070

Purity/Quality:

99% ^*data from raw suppliers

2-((5-(Chloromethyl)thiophen-2-yl)oxy)benzoicacid 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(2-CHLORO-5-THENOYL)BENZOIC ACID

There total 3 articles about 2-(2-CHLORO-5-THENOYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-thienyl chloride (96-43-5) + phthalic anhydride (85-44-9) → 2-(5-chlorothiophene-2-carbonyl)benzoic acid (136309-62-1)

Guidance literature:

With aluminium trichloride; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00077a008

Reference yield: 23.0%

methyl 5-chloro-2-thiophenecarboxylate (35475-03-7) + 2-bromobenzoic-acid (88-65-3) → 2-(5-chlorothiophene-2-carbonyl)benzoic acid (136309-62-1)

Guidance literature:

2-bromobenzoic-acid; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl 5-chloro-2-thiophenecarboxylate; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.5012/bkcs.2012.33.7.2389

Reference yield:

phthalic anhydride (85-44-9) → 2-(5-chlorothiophene-2-carbonyl)benzoic acid (136309-62-1)

Guidance literature:

With methoxybenzene;

DOI:10.1021/jo01139a007

upstream raw materials:

2-thienyl chloride

phthalic anhydride

methyl 5-chloro-2-thiophenecarboxylate

2-bromobenzoic-acid

Downstream raw materials:

4-(5-chlorothiophen-2-yl)-2-[3-[4-[3-(acetylamino)phenyl]piperidine-1-yl]propyl]phthalazin-1(2H)-one

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