(R)-Ethyl chroman-2-carboxylate

Base Information

Chemical Name:(R)-Ethyl chroman-2-carboxylate
CAS No.:137590-28-4
Molecular Formula:C12H14O3
Molecular Weight:206.241
Hs Code.:
DSSTox Substance ID:DTXSID101218465
Mol file:137590-28-4.mol

Synonyms:137590-28-4;(R)-Ethyl chroman-2-carboxylate;SCHEMBL9739640;(R)-Ethylchroman-2-carboxylate;DTXSID101218465;ETHYL (2R)-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-CARBOXYLATE

Suppliers and Price of (R)-Ethyl chroman-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (R)-Ethyl chroman-2-carboxylate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:206.094294304
Heavy Atom Count:15
Complexity:227

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CCC2=CC=CC=C2O1
Isomeric SMILES:CCOC(=O)[C@H]1CCC2=CC=CC=C2O1

Technology Process of (R)-Ethyl chroman-2-carboxylate

There total 2 articles about (R)-Ethyl chroman-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 24698-77-9
ethyl Chroman-2-carboxylate

: 137590-28-4
ethyl 2,3-dihydrobenzopyran-(2R)-carboxylate

Guidance literature:: In water;
DOI:10.1002/jhet.5570290223

Reference yield: 42.0%

: 24698-77-9
ethyl Chroman-2-carboxylate

: 137590-28-4
ethyl 2,3-dihydrobenzopyran-(2R)-carboxylate

: 83780-46-5
(2S)-3,4-dihydro-2H-chromene-2-carboxylic acid

Guidance literature:: With lipase from Pseudomonas fluorescens; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; pH=8; optical yield given as %ee; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1021/jm2007886

Reference yield:

: 137590-28-4
ethyl 2,3-dihydrobenzopyran-(2R)-carboxylate

: 109210-00-6
(2R)-benzyl-6-(formyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / NaBH₄ / tetrahydrofuran; H₂O / Ambient temperature

2: 94 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 85 percent / cuprous bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / 2.5 h / 0 °C

4: 1.) POCl₃ / 1.) 15 min, 2.) a.) CH₂Cl₂, RT, 15 min, b.) 65 deg C, 1 h

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1002/jhet.5570290223