(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol

Base Information

Chemical Name:(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol
CAS No.:137590-29-5
Molecular Formula:C10H12O2
Molecular Weight:164.204
Hs Code.:
DSSTox Substance ID:DTXSID101263060
Nikkaji Number:J1.377.563J
Mol file:137590-29-5.mol

Synonyms:(r)-chroman-2-ylmethanol;137590-29-5;(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol;(R)-Chroman-2-methanol;(R)-2-hydroxymethylchroman;SCHEMBL5722925;KDLVSGWUKFJFTL-SECBINFHSA-N;DTXSID101263060;TS-02194;(2R)-3,4-Dihydro-2H-1-benzopyran-2-methanol;(-)-(R)-3.4-dihydro-2H-1-benzopyran -2-methanol

Suppliers and Price of (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:164.083729621
Heavy Atom Count:12
Complexity:147

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=CC=CC=C2OC1CO
Isomeric SMILES:C1CC2=CC=CC=C2O[C@H]1CO

Technology Process of (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol

There total 3 articles about (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 137590-29-5
(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: magnesium / tetrahydrofuran

2: sodium hydride; ethanethiol / N,N-dimethyl-formamide / Reflux

3: iodine; (11bR)-4-((4-(tert-butyl)-2,6-dimethylphenyl)amino)-2,6-bis(triphenylsilyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide; N-chloro-succinimide / toluene / 12 h / -60 °C

4: N,N-dimethyl-formamide / 12 h / Reflux

5: lithium hydroxide / methanol / 2 h / 0 °C

With N-chloro-succinimide; (11bR)-4-((4-(tert-butyl)-2,6-dimethylphenyl)amino)-2,6-bis(triphenylsilyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide; iodine; sodium hydride; magnesium; ethanethiol; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jacs.8b02607

Reference yield:

: 24698-77-9
ethyl Chroman-2-carboxylate

: 137590-29-5
(-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / H₂O

2: 94 percent / NaBH₄ / tetrahydrofuran; H₂O / Ambient temperature

With sodium tetrahydroborate; In tetrahydrofuran; water;
DOI:10.1002/jhet.5570290223