2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol

Base Information

Chemical Name:2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol
CAS No.:137718-76-4
Molecular Formula:C9H12BrNO2
Molecular Weight:246.104
Hs Code.:
DSSTox Substance ID:DTXSID10568328
Wikidata:Q82454551

Synonyms:137718-76-4;2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol;DTXSID10568328;EN300-1897834

Suppliers and Price of 2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:245.00514
Heavy Atom Count:13
Complexity:157

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCC1=C(C(=C(C=C1)OC)O)Br

Technology Process of 2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol

There total 1 articles about 2-Bromo-6-methoxy-3-[(methylamino)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 2973-58-2
2-bromoisovanillin

: 74-89-5
methylamine

: 137718-76-4
N-methyl-2-bromo-3-hydroxy-4-methoxybenzenemethanamine

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; water; for 36h;
DOI:10.1021/jo00028a066

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 137718-76-4
N-methyl-2-bromo-3-hydroxy-4-methoxybenzenemethanamine

: 137718-77-5
(2-Bromo-3-hydroxy-4-methoxy-benzyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; 1.) -78 deg C, 3 h, 2.) room temperature, 2 h;
DOI:10.1021/jo00028a066

Reference yield:

: 137718-76-4
N-methyl-2-bromo-3-hydroxy-4-methoxybenzenemethanamine

: 137718-80-0
{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / Et₃N / tetrahydrofuran / 1.) -78 deg C, 3 h, 2.) room temperature, 2 h

2: 64 percent / NaOH / n-Bu₄NBr / H₂O; CH₂Cl₂ / 36 h / Ambient temperature

With sodium hydroxide; triethylamine; tetrabutylammomium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00028a066