1,2,3,4-Tetrahydro-N-methylcarbazole

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-N-methylcarbazole
• CAS No.: 6303-88-4
• Molecular Formula: C13H15 N
• Molecular Weight: 185.269
• Hs Code.: 2933990090
• NSC Number: 42986,10148
• DSSTox Substance ID: DTXSID90212317
• Nikkaji Number: J1.051.914D,J3.174.758I
• Wikidata: Q83087397
• Mol file: 6303-88-4.mol

Synonyms:1,2,3,4-Tetrahydro-N-methylcarbazole;6303-88-4;9-methyl-1,2,3,4-tetrahydrocarbazole;9-Methyl-2,3,4,9-tetrahydro-1H-carbazole-6-D;N-methyl-tetrahydrocarbazole;107651-00-3;1H-Carbazole,2,3,4,9-tetrahydro-9-methyl-;NSC10148;n-methyltetrahydrocarbazole;9-methyl-2,3,4,9-tetrahydro-1H-carbazole;SCHEMBL3927394;DTXSID90212317;LXRZSWPAXJBXQM-UHFFFAOYSA-N;NSC42986;MFCD31699974;NSC 10148;NSC 42986;NSC-10148;NSC-42986;AKOS003594344;SY246284;SR-01000512712;SR-01000512712-1

Chemical Property of 1,2,3,4-Tetrahydro-N-methylcarbazole

Chemical Property:

• Vapor Pressure: 0.000178mmHg at 25°C
• Melting Point: 50 °C
• Boiling Point: 339.7 °C at 760 mmHg
• Flash Point: 159.2 °C
• PSA: 4.93000
• Density: 1.11 g/cm³
• LogP: 3.05710
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 185.120449483
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

99% ^*data from raw suppliers

9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(CCCC2)C3=CC=CC=C31

Technology Process of 1,2,3,4-Tetrahydro-N-methylcarbazole

There total 5 articles about 1,2,3,4-Tetrahydro-N-methylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-(N-methylanilino)cyclohexanone (38253-19-9) → 9-methyl-2,3,4,9-tetrahydro-1H-carbazole (6303-88-4) + 7-phenyl-7-azabicyclo<4.2.0>octan-1-ol (38253-25-7) + N-methylaniline (100-61-8)

Guidance literature:

In diethyl ether; for 20h; Irradiation;

Reference yield: 24.0%

6-methyl-5,11-dihydro-6H-5a,10b-butanoindolo[2,3-b]quinoline → 9-methyl-2,3,4,9-tetrahydro-1H-carbazole (6303-88-4) + 2-((9-methyl-2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl)aniline + 2-((9-methyl-2,3,4,9-tetrahydro-1H-carbazol-8-yl)methyl)aniline

Guidance literature:

With indium(III) triflate; In 1,2-dichloro-ethane; at 80 ℃; for 12h;

DOI:10.1002/ejoc.201700432

Reference yield:

N,N'-dimethyl-N-phenyl-N'-(1-cyclohexenyl)hydrazine (23061-00-9) → 9-methyl-2,3,4,9-tetrahydro-1H-carbazole (6303-88-4) + methylamine (74-89-5)

Guidance literature:

In ethylene glycol; at 60 ℃; Thermodynamic data; Rate constant; Mechanism; ΔH(excit.), ΔS(excit.), var. temp., var. solvents, acid-catalyzed reaction, presence of CH3ONa;

DOI:10.1007/BF00515065

upstream raw materials:

N,N'-dimethyl-N-phenyl-N'-(1-cyclohexenyl)hydrazine

2-(N-methylanilino)cyclohexanone

N-methylcarbazole

Downstream raw materials:

N-Methyl-1,2,3,4,5,6,7,8-octahydrocarbazol

N-methylcarbazole

9-methyl-6-nitro-2,3,4,9-tetrahydro-1H-carbazole

(±)-9-methyl-2,3,4,4a,9,9a-hexahydro-1H-carbazole