L-Leucine, N-[N-[N-[2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-3-oxo-1-butenyl]glycyl ]-L-phenylalanyl]-, methyl ester

Base Information

Chemical Name:L-Leucine, N-[N-[N-[2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-3-oxo-1-butenyl]glycyl ]-L-phenylalanyl]-, methyl ester
CAS No.:138524-55-7
Molecular Formula:C29H37N5O6
Molecular Weight:551.643
Hs Code.:
Mol file:138524-55-7.mol

Synonyms:

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Chemical Property of L-Leucine, N-[N-[N-[2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-3-oxo-1-butenyl]glycyl ]-L-phenylalanyl]-, methyl ester

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Technology Process of L-Leucine, N-[N-[N-[2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-3-oxo-1-butenyl]glycyl ]-L-phenylalanyl]-, methyl ester

There total 5 articles about L-Leucine, N-[N-[N-[2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-3-oxo-1-butenyl]glycyl ]-L-phenylalanyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 38155-19-0
L-phenylalanyl-L-leucine methyl ester

: 138524-52-4
[(Z)-2-(6-Methyl-pyridin-2-ylcarbamoyl)-3-oxo-but-1-enylamino]-acetic acid

: 138524-55-7
(S)-4-Methyl-2-((S)-2-{2-[(E)-2-(6-methyl-pyridin-2-ylcarbamoyl)-3-oxo-but-1-enylamino]-acetylamino}-3-phenyl-propionylamino)-pentanoic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 5 ℃; for 1h;
DOI:10.1002/jhet.5570280715

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 138524-55-7
(S)-4-Methyl-2-((S)-2-{2-[(E)-2-(6-methyl-pyridin-2-ylcarbamoyl)-3-oxo-but-1-enylamino]-acetylamino}-3-phenyl-propionylamino)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / xylene / 2 h / Heating

2: 72 percent / CH₂Cl₂ / 1.) r.t., 1 h, 2.) reflux, 20 min

3: 84 percent / ethanol / 1 h / Heating

4: 68 percent / aq. KOH / Ambient temperature

5: 56 percent / N-methylmorpholine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / 0 - 5 °C

With 4-methyl-morpholine; potassium hydroxide; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; xylene;
DOI:10.1002/jhet.5570280715

Reference yield:

: 16867-47-3
N-(2-amino-6-methyl-pyridinyl)ketoacetamide

: 138524-55-7
(S)-4-Methyl-2-((S)-2-{2-[(E)-2-(6-methyl-pyridin-2-ylcarbamoyl)-3-oxo-but-1-enylamino]-acetylamino}-3-phenyl-propionylamino)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / CH₂Cl₂ / 1.) r.t., 1 h, 2.) reflux, 20 min

2: 84 percent / ethanol / 1 h / Heating

3: 68 percent / aq. KOH / Ambient temperature

4: 56 percent / N-methylmorpholine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / 0 - 5 °C

With 4-methyl-morpholine; potassium hydroxide; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;
DOI:10.1002/jhet.5570280715