N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

Base Information

Chemical Name:N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine
CAS No.:288249-90-1
Molecular Formula:C₂₄H₂₃FN₄O₄
Molecular Weight:450.469
Hs Code.:

Synonyms:

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Chemical Property of N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

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Technology Process of N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

There total 12 articles about N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

: 288249-90-1
N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

Guidance literature:: With sodium hydroxide; In ethanol; water; for 0.5h; Heating / reflux;

Reference yield:

: 138907-68-3
ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 288249-90-1
N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

Guidance literature:: Multi-step reaction with 5 steps

1: isopentyl nitrite / tetrahydrofuran / 2 h / Heating / reflux

2: sodium hydroxide / ethanol; water / 0.5 h / Heating / reflux

3: thionyl chloride / 1,2-dichloro-ethane / 1 h / 83 °C

4: pyridine / 1 h / Cooling with ice

5: sodium hydroxide / ethanol; water / 0.5 h / Heating / reflux

With sodium hydroxide; thionyl chloride; isopentyl nitrite; In tetrahydrofuran; pyridine; ethanol; water; 1,2-dichloro-ethane;

Reference yield:

: 16588-15-1
2-chloro-5-nitro-benzamide

: 288249-90-1
N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)pyrazol-4-ylcarbonyl]glycine

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzenesulfonyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 - 145 °C

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / Ice cooling

3.1: iron; ammonium chloride / ethanol; water / 0.83 h / 65 °C / Heating / reflux

4.1: triethylamine / tetrahydrofuran / 4 h / 20 °C / Ice cooling

5.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1.5 h / 20 °C / Cooling with ice

5.2: 1 h / Cooling with ice

6.1: trifluoroacetic acid / 1 h / 20 °C

7.1: pyridine / 1 h / Cooling with ice

8.1: sodium hydroxide / ethanol; water / 0.5 h / Heating / reflux

With sodium hydroxide; iron; sodium hydride; ammonium chloride; triethylamine; benzenesulfonyl chloride; trifluoroacetic acid; In tetrahydrofuran; pyridine; DMF (N,N-dimethyl-formamide); ethanol; water; toluene;