(6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione

Base Information

Chemical Name:(6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS No.:24703-12-6
Molecular Formula:C₂₂H₂₉FO₆
Molecular Weight:408.467
Hs Code.:

Synonyms:Pregna-1,4-diene-3,20-dione,9-fluoro-6b,11b,17,21-tetrahydroxy-16b-methyl- (8CI); 6b-Hydroxybetamethasone; 9a-Fluoro-16b-methyl-6b,11b,17a,21-tetrahydroxypregna-1,4-diene-3,20-dione

Suppliers and Price of (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione

Chemical Property:

Vapor Pressure:1.34E-17mmHg at 25°C
Boiling Point:613.2°Cat760mmHg
Flash Point:324.6°C
Density:1.38g/cm³

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione

There total 2 articles about (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 50-02-2
dexamethasone

: 11-Dehydrodexamethasone

: C₂₂H₂₉FO₆

: C₂₂H₂₇FO₆

: 24703-12-6,55879-47-5
6alpha-Hydroxydexamethasone

Guidance literature:: With Bacillus megaterium DSM₃₁₉ CYP₁₀₆A₁; In aq. phosphate buffer; for 24h; pH=7.4; Enzymatic reaction;
DOI:10.1016/j.febslet.2015.07.011

Reference yield:

: 5593-20-4
betamethasone dipropionate

: 378-44-9
betamethasone

: 5534-13-4
Betamethasone propionate

: 24703-00-2,24703-12-6,55879-47-5
6β-hydroxybetamethasone

: 78144-00-0,91677-33-7
6β-hydroxybetamethasone 17-propionate

Guidance literature:: With phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat; at 37 ℃; for 1h; Product distribution; metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo;
DOI:10.1016/S0039-128X(81)90348-2