NSC5844

Base Information

• Chemical Name: NSC5844
• CAS No.: 140926-75-6
• Molecular Formula: C20H16Cl2N4
• Molecular Weight: 383.27400
• Mol file: 140926-75-6.mol

Synonyms:N,N'-Bis-(7-chlor-[4]chinolyl)-aethylendiamin;N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine,N,N'-bis(7-chloro-4-quinolinyl);N,N'-bis-(7-chloro-[4]quinolyl)-ethylenediamine;

Chemical Property of NSC5844

Chemical Property:

• Boiling Point: 632.6±55.0 °C(Predicted)
• PKA: 6.61±0.50(Predicted)
• PSA: 49.84000
• Density: 1.431±0.06 g/cm3(Predicted)
• LogP: 5.75980

Purity/Quality:

97% ^*data from raw suppliers

N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.

Technology Process of NSC5844

There total 2 articles about NSC5844 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + ethylenediamine (107-15-3,85404-18-8) → N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine (140926-75-6)

Guidance literature:

With triethylamine; In various solvent(s); Heating;

DOI:10.1021/jm00089a025

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) + ethylenediamine (107-15-3,85404-18-8) → N-(7-chloroquinolin-4-yl)ethylenediamine (5407-57-8) + N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine (140926-75-6)

Guidance literature:

With phenol;

upstream raw materials:

4,7-dichloroquinoline

ethylenediamine