Technology Process of 5-Hexenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-,
phenylmethyl ester, (S)-
There total 6 articles about 5-Hexenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-,
phenylmethyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester;
With
zinc;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
3-chloroprop-1-ene;
With
copper(I) bromide;
In
N,N-dimethyl-formamide;
at -15 ℃;
DOI:10.1021/acs.jmedchem.8b00819
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 20 °C
2.1: triphenylphosphine; pyridine; iodine / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
3.1: zinc / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere
3.2: -15 °C
With
pyridine; iodine; potassium carbonate; triphenylphosphine; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00819
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 20 °C
2.1: triphenylphosphine; pyridine; iodine / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
3.1: zinc / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere
3.2: -15 °C
With
pyridine; iodine; potassium carbonate; triphenylphosphine; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00819
