Technology Process of Phosphinic acid, phenyl(2,4,6-trimethylphenyl)-, methyl ester, (S)-
There total 8 articles about Phosphinic acid, phenyl(2,4,6-trimethylphenyl)-, methyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
mesityl(α-methylbenzylamino)phenylphosphine;
With
borane-THF;
In
tetrahydrofuran;
With
diethylamine;
at 50 ℃;
for 16h;
methanol;
With
sulfuric acid;
for 5h;
Title compound not separated from byproducts;
Heating;
DOI:10.1023/B:RUGC.0000031849.78207.1c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Et3N / benzene / 20 °C
2.1: BH3*THF / tetrahydrofuran
2.2: Et2NH / 16 h / 50 °C
2.3: sulfuric acid / 5 h / Heating
With
borane-THF; triethylamine;
In
tetrahydrofuran; benzene;
DOI:10.1023/B:RUGC.0000031849.78207.1c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 76 percent / diethyl ether / a) 0 deg C, 2 h, 2.) RT, overnight
2: 1.) Mg, 1,2-dibromoethane / 1.) Et2O, reflux, 3 h, 2.) Et2O, a) 0 deg C, 5 h, b) RT, overnight
3: 15percent H2O2 / acetone / 4 h / Heating
4: conc. HCl / acetone / 144 h / Ambient temperature
5: 1.) SO2Cl2, 2.) Et3N / 1.) reflux, 2 h, 2.) Et2O, a) 0 deg C, 2 h, b) RT, 5 h
6: 98percent H2SO4 / 5 h / Heating
With
hydrogenchloride; sulfuryl dichloride; sulfuric acid; dihydrogen peroxide; magnesium; ethylene dibromide; triethylamine;
In
diethyl ether; acetone;
