N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide
CAS No.:64511-28-0
Molecular Formula:C20H27 N3 O4 S
Molecular Weight:405.5111
Hs Code.:
DSSTox Substance ID:DTXSID00983081
Nikkaji Number:J409.726B
ChEMBL ID:CHEMBL41729

Synonyms:BRN 0579437;Methanesulfonamide, N-(4-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)-;N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide;64511-28-0;CHEMBL41729;SCHEMBL2020737;C20H27N3O4S;DTXSID00983081;C20-H27-N3-O4-S;LS-90136;N-[4-[2-Hydroxy-3-(4-phenyl-1-piperazinyl)propyloxy]phenyl]methanesulfonamide;N-{4-[2-Hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl}methanesulfonamide

Suppliers and Price of N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide

Chemical Property:

Vapor Pressure:5.89E-16mmHg at 25°C
Boiling Point:614.5°Cat760mmHg
Flash Point:325.4°C
Density:1.293g/cm³
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:405.17222752
Heavy Atom Count:28
Complexity:546

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)NC1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC=C3)O

Technology Process of N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide

There total 5 articles about N-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 64511-28-0
1-(4-methanesulfonylamino-phenoxy)-3-(4-phenyl-piperazin-1-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1 N NaOH / 10 h

2: ethanol / 4 h / Heating

3: H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

4: dimethylformamide / 1 h / 0 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00109a007

Reference yield:

: 125228-75-3
4-nitrophenyl 2-oxiranylmethyl ether

: 64511-28-0
1-(4-methanesulfonylamino-phenoxy)-3-(4-phenyl-piperazin-1-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 4 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

3: dimethylformamide / 1 h / 0 °C

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00109a007

Reference yield:

: 64511-26-8
1-(4-nitro-phenoxy)-3-(4-phenyl-piperazin-1-yl)-propan-2-ol

: 64511-28-0
1-(4-methanesulfonylamino-phenoxy)-3-(4-phenyl-piperazin-1-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

2: dimethylformamide / 1 h / 0 °C

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00109a007