2-(Dimethylamino)propan-1-ol

Base Information

• Chemical Name: 2-(Dimethylamino)propan-1-ol
• CAS No.: 15521-18-3
• Deprecated CAS: 133814-25-2
• Molecular Formula: C5H13NO
• Molecular Weight: 103.164
• Hs Code.: 2922199090
• European Community (EC) Number: 239-558-7
• NSC Number: 26882,17707
• DSSTox Substance ID: DTXSID20871239
• Nikkaji Number: J112.299A
• Mol file: 15521-18-3.mol

Synonyms:N,N-dimethylalaninol

Chemical Property of 2-(Dimethylamino)propan-1-ol

Chemical Property:

• Vapor Pressure: 3.62mmHg at 25°C
• Melting Point: 29.84°C (estimate)
• Refractive Index: 1.436
• Boiling Point: 133.8 °C at 760 mmHg
• PKA: 14.69±0.10(Predicted)
• Flash Point: 32.1 °C
• PSA: 23.47000
• Density: 0.887 g/cm³
• LogP: -0.07120
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 103.099714038
• Heavy Atom Count: 7
• Complexity: 45.3

Purity/Quality:

99% ^*data from raw suppliers

2-(Dimethylamino)propan-1-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)N(C)C
• Use Description: DL-2-Dimethylamino-1-propanol, a chemical compound, has several applications in different fields. In the pharmaceutical and medicinal sector, it serves as a chiral auxiliary in asymmetric synthesis, facilitating the production of enantiomerically pure pharmaceutical compounds. Its role is crucial in the development of medications, ensuring that only the desired enantiomer is produced, reducing side effects and improving drug efficacy. Additionally, in the field of organic chemistry, it can function as a versatile reagent in various chemical transformations, contributing to the synthesis of complex organic molecules. Furthermore, in the cosmetic and personal care industries, DL-2-DIMETHYLAMINO-1-PROPANOL may find use in the formulation of skincare products, particularly in the creation of pH-adjusting agents and emulsifiers. Its significance varies across these fields, but it consistently plays a key role in enhancing the efficiency and specificity of chemical reactions and the development of safe and effective pharmaceuticals and cosmetic products.

Technology Process of 2-(Dimethylamino)propan-1-ol

There total 9 articles about 2-(Dimethylamino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Amino-1-propanol (6168-72-5) → 2-(dimethylamino)propan-1-ol (15521-18-3,133814-25-2)

Guidance literature:

With formic acid;

Reference yield:

2-chloro-1-dimethylaminopropane (108-14-5) → 2-(dimethylamino)propan-1-ol (15521-18-3,133814-25-2)

Guidance literature:

With silver(l) oxide;

DOI:10.1021/ja01195a519

Reference yield:

C59H104N2O15 → 2-(dimethylamino)propan-1-ol (15521-18-3,133814-25-2) + 2-dimethylamino-3-methoxypropanol + (2E,4E,14E,20E)-(23S,24R,25S,26S,29R,30S,31R,32R)-13,19,34,34-Tetramethoxy-8,10,14,17,24,26,30,32-octamethyl-tetratriaconta-2,4,14,20-tetraene-1,7,9,23,25,29,31-heptaol

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 23 ℃;

DOI:10.1016/S0040-4039(00)61369-2

upstream raw materials:

formaldehyd

2-Amino-1-propanol

2-chloro-1-dimethylaminopropane

ethyl 2-(N,N-dimethylamino)-propionate

Downstream raw materials:

1-Acetoxy-2-dimethylaminopropan-methiodid

(β-hydroxy-isopropyl)-trimethyl-ammonium; iodide

2-(dimethyl-amino)-1-methylethylchloride hydrochloride

2-chloro-1-dimethylaminopropane