Oxymorphone hydrochloride

Base Information

• Chemical Name: Oxymorphone hydrochloride
• CAS No.: 357-07-3
• Molecular Formula: C17H19 N O4 . Cl H
• Molecular Weight: 337.803
• European Community (EC) Number: 206-610-5
• UNII: 5Y2EI94NBC
• DSSTox Substance ID: DTXSID10189214
• Wikidata: Q27263031
• NCI Thesaurus Code: C47648
• RXCUI: 82064
• ChEMBL ID: CHEMBL1200794
• Mol file: 357-07-3.mol

Synonyms:Numorphan;Opana;Oxymorphone;oxymorphone HCl;Oxymorphone Hydrochloride

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Chemical Property of Oxymorphone hydrochloride

Chemical Property:

• Vapor Pressure: 1.39E-11mmHg at 25°C
• Boiling Point: 518.6°Cat760mmHg
• Flash Point: 267.5°C
• PSA: 70.00000
• Density: 1.5g/cm³
• LogP: 1.48510
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 337.1080858
• Heavy Atom Count: 23
• Complexity: 539

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
• Isomeric SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
• Recent ClinicalTrials: Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
• Uses: Analgesic (narcotic).
• Clinical Use: Oxymorphone is a potent μ agonist (10 times greater than morphine) that is used to treat severe pain. It is used by intramuscular, subcutaneous, intravenous, and rectal routes of administration. The intramuscular dose of oxymorphone (1 mg) has a half-life of 3 to 4 hours. It is a Schedule II drug. Oxymorphone, because of its 14-hydroxy group, has low antitussive activity.

Technology Process of Oxymorphone hydrochloride

There total 3 articles about Oxymorphone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

oxymorphone (76-41-5) → oxymorphone hydrochloride (357-07-3)

Guidance literature:

With hydrogenchloride; In water; Autoclave;

Reference yield: 73.3%

oripavine (467-04-9) → oxymorphone hydrochloride (357-07-3)

Guidance literature:

oripavine; With formic acid; dihydrogen peroxide; In water; isopropyl alcohol; at 30 ℃; for 4h;

With 5%-palladium/activated carbon; hydrogen; In water; isopropyl alcohol; at 70 ℃; for 66h; under 1380.65 - 1794.37 Torr;

In water; isopropyl alcohol; at 0 - 50 ℃; for 2h; pH=1.75;

Reference yield:

oxycodone hydrochloride (124-90-3) → oxymorphone hydrochloride (357-07-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / water / 4 h / 5 - 10 °C

2: L-methionine; methanesulfonic acid / 20 h / 50 °C

3: hydrogenchloride / water / Autoclave

With hydrogenchloride; ammonium hydroxide; methanesulfonic acid; L-methionine; In water;

upstream raw materials:

oxymorphone

oripavine

oxycodone hydrochloride

Downstream raw materials:

6β-oxymorphol

Refernces

• 1、 -. "Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone". Paragraph 0130; 0131. . Retrieved 2016/03/14.
• 2、 -. "PROCESS FOR IMPROVED OPIOID SYNTHESIS". Paragraph 00678 - 00688. . Retrieved 2014/02/15.