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CAS

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124-90-3

Oxycodone Hydrochloride, an opioid analgesic, is a white solid substance used for pain management. It is regulated as a Schedule II compound in the United States and is available under various brand names such as Oxycontin, Roxicodone, and Xanodyne. This pharmaceutical compound is intended for research and forensic applications.

124-90-3 Suppliers

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  • 124-90-3 Structure

  • Basic information

    1. Product Name: OXYCODONE HYDROCHLORIDE
    2. Synonyms: OXYCODONE HCL;OXYCODONE HYDROCHLORIDE;14-hydroxydihydrocodeinonehydrochloride;4,5-alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-onhydrochloride;4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one,hydrochloride,(5-a;dihydronehydrochloride;dihydrooxycodeinonehydrochloride;dihydroxycodeinonehydrochloride
    3. CAS NO:124-90-3
    4. Molecular Formula: C18H21NO4*ClH
    5. Molecular Weight: 351.82
    6. EINECS: 204-717-1
    7. Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 124-90-3.mol

  • Chemical Properties

    1. Melting Point: 261-2630C
    2. Boiling Point: 501.6 °C at 760 mmHg
    3. Flash Point: 11℃
    4. Appearance: White solid
    5. Density: 1.39 g/cm3
    6. Vapor Pressure: 7.02E-11mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene.
    10. Water Solubility: 142.9g/L(temperature not stated)
    11. CAS DataBase Reference: OXYCODONE HYDROCHLORIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: OXYCODONE HYDROCHLORIDE(124-90-3)
    13. EPA Substance Registry System: OXYCODONE HYDROCHLORIDE(124-90-3)

  • Safety Data

    1. Hazard Codes: Xn,T,F
    2. Statements: 22-39/23/24/25-23/24/25-11
    3. Safety Statements: 36/37-45-16-7
    4. RIDADR: UN 1230 3/PG 2
    5. WGK Germany: 3
    6. RTECS: QD2470000
    7. HazardClass: 6.1(a)
    8. PackingGroup: II
    9. Hazardous Substances Data: 124-90-3(Hazardous Substances Data)

124-90-3 Usage

Uses

Used in Pharmaceutical Industry:
Oxycodone Hydrochloride is used as a controlled substance (opiate) for the management of moderate to severe pain. It is an effective analgesic (narcotic) that helps alleviate pain by binding to opioid receptors in the brain, spinal cord, and other areas of the body, providing relief to patients suffering from various types of pain.
Used in Research and Forensic Applications:
Oxycodone Hydrochloride serves as an analytical reference standard in the pharmaceutical industry, aiding in the development and testing of new drugs and therapies. It is also used in forensic applications to identify and analyze the presence of the substance in cases involving drug-related crimes or incidents.

Originator

Oxyfast,Purdue Pharma, L.P.

Therapeutic Function

Narcotic analgesic

Biological Activity

Potent and selective μ -opioid receptor agonist (K i values are 16 and >1000 nM for hMOR1 and hKOR1 respectively).

Clinical Use

Oxycodone is about equipotent with morphine, but because of the 3-OCH group, it has a much lower oral:parenteral dose ratio. Thus, oxycodone is used orally to treat severe to moderate pain. It is a drug as a single agent and when combined in strong analgesic mixtures. Oxycodone has a plasma half-life of approximately 4 hours and requires dosing every 4 to 6 hours.

Drug interactions

Potentially hazardous interactions with other drugs Analgesics: possible opioid withdrawal with buprenorphine and pentazocine. Antibacterials: metabolism possibly increased by rifampicin; metabolism inhibited by telithromycin. Antidepressants: CNS excitation or depression with MAOIs - avoid; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics. Antifungals: concentration increased by voriconazole. Antihistamines: increased sedative effects with sedating antihistamines. Antipsychotics: enhanced hypotensive and sedative effects. Antivirals: concentration possibly increased by ritonavir. Dopaminergics: avoid with selegiline. Nalmefene: avoid concomitant use. Sodium oxybate: enhanced effect of sodium oxybate - avoid.

Metabolism

Oxycodone is metabolised in the liver to produce noroxycodone via the CYP3A system, oxymorphone via the CYP2D6 system and various conjugated glucuronides. The analgesic effects of the metabolites are clinically insignificant. Both metabolites undergo glucuronidation and are excreted with unchanged drug in urine.

Check Digit Verification of cas no

The CAS Registry Mumber 124-90-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 124-90:
(5*1)+(4*2)+(3*4)+(2*9)+(1*0)=43
43 % 10 = 3
So 124-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H21NO4.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;/h3-4,13,16,21H,5-9H2,1-2H3;1H/t13-,16+,17+,18-;/m1./s1

124-90-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name oxycodone hydrochloride

1.2 Other means of identification

Product number -
Other names Oxycodone hydrochloride,(5α)-4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-onehydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124-90-3 SDS

124-90-3Related news

Original ReportSafety and Efficacy of Once-Daily Hydromorphone Extended-Release Versus Twice-Daily OXYCODONE HYDROCHLORIDE (cas 124-90-3) Controlled-Release in Chinese Patients With Cancer Pain: A Phase 3, Randomized, Double-Blind, Multicenter Study10/01/2019

Noninferiority of the efficacy of once-daily hydromorphone hydrochloride extended-release (hydromorphone ER) compared with twice-daily oxycodone hydrochloride controlled-release (oxycodone CR) was investigated in this randomized, double-blind study in Chinese patients with moderate to severe can...detailed

Original ArticleMicrobiological and Physicochemical Stability of OXYCODONE HYDROCHLORIDE (cas 124-90-3) Solutions for Patient-Controlled Delivery Systems09/10/2019

ContextThe use of patient-controlled analgesia (PCA) allows patients to be managed at home and may increase the quality of life of patients with regard to drug administration. To ensure that intact drug is delivered to the patient in this setting, it is important to study its microbiological and...detailed

Original research articlePharmacokinetics of OXYCODONE HYDROCHLORIDE (cas 124-90-3) and three of its metabolites after intravenous administration in Chinese patients with pain09/09/2019

ObjectivesThe aim of this study is to evaluate the pharmacokinetic profile of oxycodone and three of its metabolites, noroxycodone, oxymorphone and noroxymorphone after intravenous administration in Chinese patients with pain.detailed

Case ReportPremedication with fast-acting OXYCODONE HYDROCHLORIDE (cas 124-90-3) hydrate effectively reduced oxaliplatin-induced severe vascular pain09/08/2019

Oxaliplatin is a platinum-based chemotherapeutic agent that holds a prominent position in the treatment of colorectal and gastric cancers. However, severe oxaliplatin-related vascular pain can be problematic for patients. Here we describe seven patients who experienced severe vascular pain cause...detailed

124-90-3Relevant articles and documents

Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone

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, (2016/03/14)

Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.

SYNTHESIS OF OXYCODONE HYDROCHLORIDE

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, (2015/06/24)

Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.

CONVERSION OF OXYCODONE BASE TO OXYCODONE HYDROCHLORIDE

-

, (2015/06/24)

Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.

PROCESS FOR IMPROVED OPIOID SYNTHESIS

-

Paragraph 00550-00558, (2014/02/15)

Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

A METHOD FOR PREPARING OXYCODONE

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Page/Page column 31; 32, (2014/02/16)

The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6α-oxycodol in an amount ≤ about 0.800 area % as determined by HPLC.

PROCESS FOR THE SYNTHESIS AND PURIFICATION OF OXYCODONE

-

, (2012/01/15)

A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8, 14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14- hydroxycodeinone and can be readily separated from oxycodone.

Preparation of low impurity opiates in a continuous flow reactor

-

Page/Page column 6, (2011/11/01)

The present invention relates to a novel process for preparing opiates or salts thereof. More particularly, the present invention relates to oxidizing the starting material in a continuous flow reactor, followed by either an isolation of the intermediate, or a direct reduction reaction.

Process For Preparing Oxycodone Having Reduced Levels Of 14-Hydroxycodeinone

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Page/Page column 6, (2008/12/06)

The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.

Process for Reducing Impurities in Oxycodone Base

-

Page/Page column 6, (2008/12/05)

The present invention is directed to a process for using n-butanol to prepare an oxycodone base compositions having reduced levels of impurities such as 14-hydroxycodeinone and DHDHC.