1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-

Base Information

• Chemical Name: 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-
• CAS No.: 143191-63-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol file: 143191-63-3.mol

Synonyms:

Chemical Property of 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-

There total 12 articles about 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(Z)-1-(4-methoxyphenyl)-1-(tert-butyldimethylsiloxy)-1-propene (143215-10-5) → (R)-(+)-2-hydroxy-1-(4-methoxyphenyl)-1-propan-1-one (143191-63-3)

Guidance literature:

With methanesulfonamide; AD-mix-β; In water; tert-butyl alcohol; at 0 ℃; for 16h;

DOI:10.1021/jo00045a011

Reference yield: 75.0%

phosphoric acid diethyl ester 1-(4-methoxyphenyl)-propenyl ester (530085-88-2) → (R)-(+)-2-hydroxy-1-(4-methoxyphenyl)-1-propan-1-one (143191-63-3)

Guidance literature:

With AD-mix-β; methanesulfonamide; In water; tert-butyl alcohol; at 0 ℃; for 16h; enantioselective reaction;

DOI:10.1016/j.tetasy.2012.09.012

Reference yield: 64.0%

4-methoxy-benzaldehyde (123-11-5) + acetaldehyde (75-07-0,9002-91-9) → (R)-(+)-2-hydroxy-1-(4-methoxyphenyl)-1-propan-1-one (143191-63-3)

Guidance literature:

With thiamine diphosphate; magnesium sulfate; benzaldehyde lyase; In phosphate buffer; dimethyl sulfoxide; at 25 ℃; pH=7.0; Enzymatic reaction;

DOI:10.1002/1615-4169(200201)344:1<96::AID-ADSC96>3.0.CO;2-Z

upstream raw materials:

(Z)-1-methoxy-1-(4-methoxyphenyl)-1-propene

(Z)-1-(4-methoxyphenyl)-1-(tert-butyldimethylsiloxy)-1-propene

1-(4-methoxyphenyl)-1-oxopropan-2-yl acetate

4-methoxy-benzaldehyde