2-Fluoroisoniazide

Base Information

• Chemical Name: 2-Fluoroisoniazide
• CAS No.: 369-24-4
• Molecular Formula: C₆H₆FN₃O
• Molecular Weight: 155.132
• Hs Code.: 2933399090
• Mol file: 369-24-4.mol

Synonyms:Isonicotinicacid, 2-fluoro-, hydrazide (8CI); INHd 43; NSC 280613

Chemical Property of 2-Fluoroisoniazide

Chemical Property:

• Appearance/Colour: off white powder
• Vapor Pressure: 5.31E-07mmHg at 25°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 68.01000
• Density: 1.356 g/cm³
• LogP: 0.91540

Purity/Quality:

99%, ^*data from raw suppliers

2-Fluoroisonicotinohydrazide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoroisoniazide

There total 3 articles about 2-Fluoroisoniazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-fluoropyridine-4-carboxylic acid (402-65-3) → 2-fluoro-isonicotinic acid hydrazide (369-24-4)

Guidance literature:

2-fluoropyridine-4-carboxylic acid; With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 23 ℃; for 0.25h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 23 ℃; for 1.08333h; Cooling with ice;

DOI:10.1016/j.tube.2021.102100

Reference yield:

2-fluoro-isonicotinic acid methyl ester (455-69-6) → 2-fluoro-isonicotinic acid hydrazide (369-24-4)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01104a046

Reference yield:

ethyl 2-fluoroisonicotinate (123412-95-3) → 2-fluoro-isonicotinic acid hydrazide (369-24-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 12h; Reflux;

upstream raw materials:

2-fluoro-isonicotinic acid methyl ester

2-fluoropyridine-4-carboxylic acid

ethyl 2-fluoroisonicotinate

Downstream raw materials:

2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

Refernces

• 1、 -. "3. 6 - Disubstituted [1, 2, 4] triazolo [3, 4 - b] [1, 3, 4] thiadiazole compound and use thereof". Paragraph 0069; 0070. . Retrieved 2018/11/22.
• 2、 Sato, Takahiro,Ashizawa, Naoki,Matsumoto, Koji,Iwanaga, Takashi,Nakamura, Hiroshi,Inoue, Tsutomu,Nagata, Osamu. "Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia". experimental part. p. 6225 - 6229. Retrieved 2010/07/02.