2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

Base Information

• Chemical Name: 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide
• CAS No.: 1412405-56-1
• Molecular Formula: C₂₀H₂₂FN₅OS
• Molecular Weight: 399.492
• Mol file: 1412405-56-1.mol

Synonyms:2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

Chemical Property of 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

There total 6 articles about 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-((5-bromo-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide (1412405-59-4) + 2-fluoropyridin-4-ylboronic acid (401815-98-3) → 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide (1412405-56-1)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 150 ℃; for 0.75h; Microwave irradiation;

Reference yield:

2-fluoro-isonicotinic acid methyl ester (455-69-6) → 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide (1412405-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine / 0.25 h / 150 °C / Microwave irradiation

2.1: 0.25 h / 150 °C / Microwave irradiation

2.2: 16 h / Reflux

3.1: caesium carbonate / acetonitrile / 16 h

With caesium carbonate; hydrazine; In acetonitrile;

DOI:10.1016/j.bmcl.2014.04.081

Reference yield:

2-fluoro-isonicotinic acid hydrazide (369-24-4) → 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide (1412405-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.25 h / 150 °C / Microwave irradiation

1.2: 16 h / Reflux

2.1: caesium carbonate / acetonitrile / 16 h

With caesium carbonate; In acetonitrile;

DOI:10.1016/j.bmcl.2014.04.081

upstream raw materials:

2-((5-bromo-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

2-fluoropyridin-4-ylboronic acid

2-((5-amino-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide

2-fluoro-isonicotinic acid methyl ester