123412-95-3

Basic information

• Product Name: 2-FLUORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-FLUORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER;4-PYRIDINECARBOXYLIC ACID, 2-FLUORO-, ETHYL ESTER
• CAS NO: 123412-95-3
• Molecular Weight: 0
• Mol File: 123412-95-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-FLUORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER(123412-95-3)
• EPA Substance Registry System: 2-FLUORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER(123412-95-3)

Safety Data

• Hazardous Substances Data: 123412-95-3(Hazardous Substances Data)

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 402-65-3 2-fluoropyridine-4-carboxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 64-17-5 ethanol 
• 461-87-0 2-fluoro-4-methylpyridine 
• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 369-24-4 2-fluoro-isonicotinic acid hydrazide 
• 131747-60-9 (2-fluoropyridin-4-yl)methanol 

Relevant articles and documents

Electrolytic partial fluorination of organic compounds: Part 26. Anodic monofluorination of ethyl isonicotinate

Anodic fluorinations of ethyl isonicotinate (1) and related compounds have been attempted. Desired fluorinated product, 2-fluoroisonicotinate (2) was obtained in reasonable yield by direct anodic monofluorination of ethyl isonicotinate 1. The yield of 2 and the conversion of the electrochemical reaction could be improved by applying relatively lower anodic potential and by increasing the concentration of supporting electrolyte Et3N · 3HF.

C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE

The present invention provides compositions and methods for the selective C-H fluorination of nitrogen-containing heteroarenes with AgF2, which has previously been considered too reactive for practical, selective C-H fluorination. Fluorinated heteroarenes are prevalent in numerous pharmaceuticals, agrochemicals and materials. However, the reactions used to introduce fluorine into these molecules require pre-functionalized substrates or the use of F2 gas. The present invention provides a mild and general method for the C-H fluorination of nitrogen-containing heteroarene compounds to 2-fluoro-heteroarenes with commercially available AgF2. In various embodiments, these reactions occur at ambient temperature within one hour and occur with exclusive selectivity for fluorination at the 2-position. Exemplary reaction conditions are effective for fluorinating diazine heteroarenes to form a single fluorinated isomer.

Single photon emission computed tomography/positron emission tomography imaging and targeted radionuclide therapy of melanoma: New multimodal fluorinated and iodinated radiotracers

This study reports a series of 14 new iodinated and fluorinated compounds offering both early imaging (123I, 124I, 18F) and systemic treatment (131I) of melanoma potentialities. The biodistribution of each 125I-labeled tracer was evaluated in a model of melanoma B16F0-bearing mice, using in vivo serial γ scintigraphic imaging. Among this series, [125I]56 emerged as the most promising compound in terms of specific tumoral uptake and in vivo kinetic profile. To validate our multimodality concept, the radiosynthesis of [18F]56 was then optimized and this radiotracer has been successfully investigated for in vivo PET imaging of melanoma in B16F0- and B16F10-bearing mouse model. The therapeutic efficacy of [131I]56 was then evaluated in mice bearing subcutaneous B16F0 melanoma, and a significant slow down in tumoral growth was demonstrated. These data support further development of 56 for PET imaging (18F, 124I) and targeted radionuclide therapy ( 131I) of melanoma using a single chemical structure.