Z-Gly-sar-OH

Base Information

• Chemical Name: Z-Gly-sar-OH
• CAS No.: 7801-91-4
• Molecular Formula: C13H16N2O5
• Molecular Weight: 280.28
• NSC Number: 89181
• DSSTox Substance ID: DTXSID20293391
• Nikkaji Number: J307.494C
• Wikidata: Q82032094
• Mol file: 7801-91-4.mol

Synonyms:Z-GLY-SAR-OH;7801-91-4;2-[methyl-[2-(phenylmethoxycarbonylamino)acetyl]amino]acetic acid;NSC89181;Z-Ala-Sar-OH;NCIOpen2_005496;Z-Gly-Sar-OH, AldrichCPR;DTXSID20293391;MFCD00191104;NSC-89181;AS-56430;CS-0151363;N-(((benzyloxy)carbonyl)glycyl)-N-methylglycine;2-(2-(benzyloxycarbonylamino)-N-methylacetamido)acetic acid;2,4-Pyrimidinediamine,5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

Chemical Property of Z-Gly-sar-OH

Chemical Property:

• Vapor Pressure: 9.59E-12mmHg at 25°C
• Melting Point: 102 °C
• Boiling Point: 522.5°Cat760mmHg
• PKA: 3.43±0.10(Predicted)
• Flash Point: 269.8°C
• PSA: 95.94000
• Density: 1.297g/cm³
• LogP: 0.84670
• Storage Temp.: -15°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 280.10592162
• Heavy Atom Count: 20
• Complexity: 353

Purity/Quality:

97% ^*data from raw suppliers

Z-Gly-Sar-OH 99+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC(=O)O)C(=O)CNC(=O)OCC1=CC=CC=C1

Technology Process of Z-Gly-sar-OH

There total 4 articles about Z-Gly-sar-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

sarcosine (107-97-1,25951-24-0) + Z-Gly-ONp (1738-86-9) → Z-Gly-Sar-OH (7801-91-4)

Guidance literature:

DOI:10.1248/cpb.39.584

Reference yield:

sarcosine (107-97-1,25951-24-0) + N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) → Z-Gly-Sar-OH (7801-91-4)

Guidance literature:

With sodium hydroxide; unter Kuehlung;

Reference yield:

sarcosine (107-97-1,25951-24-0) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → Z-Gly-Sar-OH (7801-91-4)

Guidance literature:

Multistep reaction; (i) HN(SiMe₃)2, THF, (ii) /BRN= 526877/, carbonyldiimidazole, (iii) H₂O;

upstream raw materials:

sarcosine

N-(benzyloxycarbonyl)glycyl chloride

N-(Benzyloxycarbonyl)glycine

Z-Gly-ONp

Downstream raw materials:

Z-Gly-Sar-Arg(NO₂)-OBzl

Glycylsarcosine