C90123

Base Information

• Chemical Name: C90123
• CAS No.: 14665-31-7
• Molecular Formula: C7H4Cl2O5S
• Molecular Weight: 271.078
• Hs Code.: 2918290000
• Mol file: 14665-31-7.mol

Synonyms:4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid;4-Chloro-5-(chlorosulfonyl)-2-hydroxybenzoic acid;

Chemical Property of C90123

Chemical Property:

• Melting Point: 181-183 °C
• Boiling Point: 458.3±45.0 °C(Predicted)
• PKA: 1.00±0.10(Predicted)
• PSA: 100.05000
• Density: 1.819±0.06 g/cm3(Predicted)
• LogP: 2.75210
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-5-chlorosulfonylSalicylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-5-chlorosulfonyl Salicylic acid is used in the synthesis of Xipamide (X745150), a diuretic agent.

Technology Process of C90123

There total 2 articles about C90123 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorosalicylic acid (5106-98-9) → 4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid (14665-31-7)

Guidance literature:

With chlorosulfonic acid;

DOI:10.1002/ardp.19673000710

Reference yield:

→ 4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid (14665-31-7)

Guidance literature:

4-Chlorsalicylsaeure, Chlorsulfonsaeure;

Reference yield:

pyrrolidine (123-75-1) + 4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid (14665-31-7) → 4-chloro-2-hydroxy-5-(pyrrolidine-1-sulfonyl)benzoic acid (1610830-33-5)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.166667h;

upstream raw materials:

4-chlorosalicylic acid

Downstream raw materials:

3-nitro-4-chloro-5-chlorosulfonylsalicylic acid

3-nitro-4-chloro-5-sulfamoylsalicylic acid chloroanhydride

3-amino-4-chloro-5-sulfamoylsalicylic acid ethyl ester

3-nitro-4-chloro-5-sulfamoylsalicylic acid

Refernces

• 1、 Smirnov. "Synthesis and diuretic activity of 3-nitro(amino)-4-chloro-5-sulfamoylsalicylic acids and their derivatives". . p. 198 - 200. Retrieved 2007/10/03.
• 2、 Liebenow. "Preparation of nitrated 4-chlorosalicylic acids". . p. 625 - 629. Retrieved 2007/10/06.