3-nitro-4-chloro-5-chlorosulfonylsalicylic acid

Base Information

• Chemical Name: 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid
• CAS No.: 328553-76-0
• Molecular Formula: C₇H₃Cl₂NO₇S
• Molecular Weight: 316.075
• Mol file: 328553-76-0.mol

Synonyms:

Chemical Property of 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid

There total 2 articles about 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid (14665-31-7) → 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid (328553-76-0)

Guidance literature:

With sulfuric acid; nitric acid;

DOI:10.1002/ardp.19673000710

Reference yield:

4-chlorosalicylic acid (5106-98-9) → 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid (328553-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid; SOCl₂ / 2 h / 0 °C

2: HNO₃; H₂SO₄ / 2 h / 65 - 70 °C

With chlorosulfonic acid; thionyl chloride; sulfuric acid; nitric acid;

DOI:10.1007/BF02524597

Reference yield:

3-nitro-4-chloro-5-chlorosulfonylsalicylic acid (328553-76-0) → 3-amino-4-chloro-5-sulfamoylsalicylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / diethyl ether / 2 h / 0 °C

2: H₂ / Pd/C / methanol / 40 - 45 °C / 836 Torr

With ammonia; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1007/BF02524597

upstream raw materials:

4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid

4-chlorosalicylic acid

Downstream raw materials:

3-nitro-4-chloro-5-sulfamoylsalicylic acid

3-nitro-4-chloro-5-sulfamoylsalicylic acid chloroanhydride

3-amino-4-chloro-5-sulfamoylsalicylic acid ethyl ester

3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester