3-nitro-4-chloro-5-sulfamoylsalicylic acid

Base Information

• Chemical Name: 3-nitro-4-chloro-5-sulfamoylsalicylic acid
• CAS No.: 55691-09-3
• Molecular Formula: C₇H₅ClN₂O₇S
• Molecular Weight: 296.645
• Mol file: 55691-09-3.mol

Synonyms:3-nitro-4-chloro-5-sulfamoylsalicylic acid

Chemical Property of 3-nitro-4-chloro-5-sulfamoylsalicylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-nitro-4-chloro-5-sulfamoylsalicylic acid

There total 3 articles about 3-nitro-4-chloro-5-sulfamoylsalicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-4-chloro-5-chlorosulfonylsalicylic acid (328553-76-0) → 3-nitro-4-chloro-5-sulfamoylsalicylic acid (55691-09-3)

Guidance literature:

With ammonia; In diethyl ether; at 0 ℃; for 2h;

DOI:10.1007/BF02524597

Reference yield:

4-chlorosalicylic acid (5106-98-9) → 3-nitro-4-chloro-5-sulfamoylsalicylic acid (55691-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorosulfonic acid; SOCl₂ / 2 h / 0 °C

2: HNO₃; H₂SO₄ / 2 h / 65 - 70 °C

3: NH₃ / diethyl ether / 2 h / 0 °C

With chlorosulfonic acid; thionyl chloride; sulfuric acid; ammonia; nitric acid; In diethyl ether;

DOI:10.1007/BF02524597

Reference yield:

4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid (14665-31-7) → 3-nitro-4-chloro-5-sulfamoylsalicylic acid (55691-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃; H₂SO₄ / 2 h / 65 - 70 °C

2: NH₃ / diethyl ether / 2 h / 0 °C

With sulfuric acid; ammonia; nitric acid; In diethyl ether;

DOI:10.1007/BF02524597

upstream raw materials:

3-nitro-4-chloro-5-chlorosulfonylsalicylic acid

4-chlorosalicylic acid

4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid

Downstream raw materials:

3-nitro-4-chloro-5-sulfamoylsalicylic acid chloroanhydride

3-amino-4-chloro-5-sulfamoylsalicylic acid ethyl ester

3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester