Kachirachirol A

Base Information

• Chemical Name: Kachirachirol A
• CAS No.: 73027-11-9
• Molecular Formula: C₁₉H₁₈O₃
• Molecular Weight: 294.35
• Mol file: 73027-11-9.mol

Synonyms:Eupomatenoid 13;kachirachirol-A;4-[7-Methoxy-3-methyl-5-((E)-propenyl)-benzofuran-2-yl]-phenol;Eupomatenoid-13;

Chemical Property of Kachirachirol A

Chemical Property:

• PSA: 42.60000
• LogP: 5.15550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Kachirachirol A

There total 14 articles about Kachirachirol A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-allylguaiacol (97-53-0) → 2-(4-hydroxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofuran (73027-11-9)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogen / palladium-carbon / ethyl acetate

2: boron trifluoride / 1.5 h / 150 - 155 °C

3: mossy zinc, mercury(II) chloride, 50percent hydrochloric acid / ethanol / 12 h / Heating

4: pyridine / 36 h / Ambient temperature

5: N-bromosuccinimide / CCl₄ / 0.5 h / Heating

6: 1.) triphenylphosphine, 2.) triethylamine / 1.) acetonitrile, reflux, 2.) toluene, reflux

7: lithium aluminium hydride / diethyl ether / 0.5 h / Heating

With pyridine; hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; boron trifluoride; hydrogen; triethylamine; triphenylphosphine; mercury dichloride; zinc; palladium on activated charcoal; In tetrachloromethane; diethyl ether; ethanol; ethyl acetate;

Reference yield:

2-methoxy-4-n-propylphenol (2785-87-7) → 2-(4-hydroxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofuran (73027-11-9)

Guidance literature:

Multi-step reaction with 6 steps

1: boron trifluoride / 1.5 h / 150 - 155 °C

2: mossy zinc, mercury(II) chloride, 50percent hydrochloric acid / ethanol / 12 h / Heating

3: pyridine / 36 h / Ambient temperature

4: N-bromosuccinimide / CCl₄ / 0.5 h / Heating

5: 1.) triphenylphosphine, 2.) triethylamine / 1.) acetonitrile, reflux, 2.) toluene, reflux

6: lithium aluminium hydride / diethyl ether / 0.5 h / Heating

With pyridine; hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; boron trifluoride; triethylamine; triphenylphosphine; mercury dichloride; zinc; In tetrachloromethane; diethyl ether; ethanol;

Reference yield:

kachirachirol-A monoacetate (86253-79-4) → 2-(4-hydroxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofuran (73027-11-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.5h; Heating;

upstream raw materials:

kachirachirol-A monoacetate

4-acetoxybenzoyl chloride

4-allylguaiacol

2-methoxy-4-n-propylphenol

Downstream raw materials:

kachirachirol-A monoacetate