4-(3-BROMO-PROPOXY)-3-METHOXY-BENZALDEHYDE

Base Information

• Chemical Name: 4-(3-BROMO-PROPOXY)-3-METHOXY-BENZALDEHYDE
• CAS No.: 148433-00-5
• Molecular Formula: C11H13BrO3
• Molecular Weight: 273.126
• Mol file: 148433-00-5.mol

Synonyms:4-(3-Bromo-propoxy)-3-methoxy-benzaldehyde;4-(2-bromoethoxy)-3-methoxybenzaldehyde;vanillin 3-bromopropyl ether;

Chemical Property of 4-(3-BROMO-PROPOXY)-3-METHOXY-BENZALDEHYDE

Chemical Property:

• Melting Point: 59 - 60 °C
• PSA: 35.53000
• LogP: 2.67150

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Bromopropoxy)-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-BROMO-PROPOXY)-3-METHOXY-BENZALDEHYDE

There total 4 articles about 4-(3-BROMO-PROPOXY)-3-METHOXY-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

vanillin (121-33-5,8014-42-4) + 1,3-dibromo-propane (109-64-8) → 4-(3-bromopropoxy)-3-methoxybenzaldehyde (148433-00-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

DOI:10.1021/jm0607193

Reference yield: 71.0%

vanillin (121-33-5,8014-42-4) + 1,3-dibromo-propane (109-64-8) → 4-[3-(4-formyl-2-methoxyphenoxy)propoxy]-3-methoxybenzaldehyde (101913-37-5) + 4-(3-bromopropoxy)-3-methoxybenzaldehyde (148433-00-5)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

DOI:10.1039/d1nj03830c

Reference yield: 51.0%

1,4-dibromo-butane (110-52-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(3-bromopropoxy)-3-methoxybenzaldehyde (148433-00-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2020.112276

upstream raw materials:

vanillin

1,3-dibromo-propane

1.3-chlorobromopropane

1,4-dibromo-butane

Downstream raw materials:

3-methoxy-4-[3-(4-toluenesulfonyl)propoxy]benzaldehyde

4-(3-(3-chlorophenoxy)propoxy)-3-methoxybenzaldehyde

4-(3-(2-chlorophenoxy)propoxy)-3-methoxybenzaldehyde

3-methoxy-4-(3-(m-tolyloxy)propoxy)benzaldehyde

Refernces

• 1、 Paul, Amrita,Jana, Avijit,Karthik,Bera, Manoranjan,Zhao, Yanli,Singh, N.D. Pradeep. "Photoresponsive real time monitoring silicon quantum dots for regulated delivery of anticancer drugs". . p. 521 - 528. Retrieved 2016.
• 2、 Chen, Lijuan,Fan, Tiantian,Lei, Xiangui,Teichmann, Alexander Tobias,Wang, Amu,Wang, Chao,Wei, Zhe,Wieland, Frank Heinrich,Yang, Youzhe,Yin, Jinxiang,Zhou, Li,Zhu, Yue. "Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation". . . Retrieved 2020/03/24.