Technology Process of Naphthalene, 1,2-dihydro-4-iodo-
There total 2 articles about Naphthalene, 1,2-dihydro-4-iodo- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triphenyl phosphite; bromine; triethylamine / dichloromethane / 20 h / -60 - 20 °C / Inert atmosphere; Reflux
2.1: zinc; 5,5'-bis(trifluoromethyl)-2,2'-bipyridine nickel dibromide / N,N-dimethyl-formamide / 24 °C
2.2: 24 °C
With
triphenyl phosphite; 5,5'-bis(trifluoromethyl)-2,2'-bipyridine nickel dibromide; bromine; triethylamine; zinc;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.7b13601
- Guidance literature:
-
4-bromo-1,2-dihydronaphthalene; cyclohex-1-en-1-yl trifluoromethane sulfonate;
With
5,5'-bis(trifluoromethyl)-2,2'-bipyridine nickel dibromide; zinc;
In
N,N-dimethyl-formamide;
at 24 ℃;
With
iodine;
In
N,N-dimethyl-formamide;
at 24 ℃;
Kinetics;
DOI:10.1021/jacs.7b13601
- Guidance literature:
-
1,2-dihydro-4-iodonaphthalene;
With
diethylzinc; lithium pentane-2,4-dionate;
In
1-methyl-pyrrolidin-2-one;
at 0 ℃;
for 3h;
Inert atmosphere;
With
3,3'-bis-pyrrolidin-1-ylmethyl-[1,1']binaphthalenyl-2,2'-diol;
In
1-methyl-pyrrolidin-2-one; dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
benzaldehyde;
In
1-methyl-pyrrolidin-2-one; dichloromethane;
at 0 ℃;
for 12h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201007351