2-[(4-Methoxyphenyl)methyl]furan

Base Information

• Chemical Name: 2-[(4-Methoxyphenyl)methyl]furan
• CAS No.: 15047-76-4
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• DSSTox Substance ID: DTXSID00552150
• Nikkaji Number: J2.547.020F
• Wikidata: Q82432196
• Mol file: 15047-76-4.mol

Synonyms:2-(4-methoxybenzyl)furan;15047-76-4;2-[(4-Methoxyphenyl)methyl]furan;2-(p-anisyl)furan;DTXSID00552150

Chemical Property of 2-[(4-Methoxyphenyl)methyl]furan

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 188.083729621
• Heavy Atom Count: 14
• Complexity: 162

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC2=CC=CO2

Technology Process of 2-[(4-Methoxyphenyl)methyl]furan

There total 24 articles about 2-[(4-Methoxyphenyl)methyl]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(4-methoxyphenyl)penta-3,4-dien-2-one (168210-91-1) → 2<(4-Methoxylphenyl)methyl>furan (15047-76-4)

Guidance literature:

silver nitrate; In acetone;

DOI:10.1002/(sici)1521-3897(200001)342:1<40::aid-prac40>3.0.co;2-v

Reference yield: 89.0%

2-(tributylstannyl)furan (118486-94-5) + p-methoxybenzyl chloride (824-94-2) → 2<(4-Methoxylphenyl)methyl>furan (15047-76-4)

Guidance literature:

With bromobis(tri(2-furyl)phosphine)(N-succinimide)palladium(II); In N,N-dimethyl-formamide; at 20 ℃; for 3h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4cc09810b

Reference yield: 80.0%

furfuryl-bis-(toluene-4-sulfonyl)-amine (64209-56-9) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 2<(4-Methoxylphenyl)methyl>furan (15047-76-4)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at 70 ℃; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201100285

upstream raw materials:

(2-furyl)methyl alcohol

4-methoxyphenyl magnesium bromide

4-(fur-2-ylmethyl)phenol

methyl iodide