Phosphonic acid, (4-methoxyphenyl)-, dimethyl ester

Base Information

• Chemical Name: Phosphonic acid, (4-methoxyphenyl)-, dimethyl ester
• CAS No.: 15286-19-8
• Molecular Formula: C9H13O4P
• Molecular Weight: 216.174
• DSSTox Substance ID: DTXSID00463015
• Nikkaji Number: J1.901.741I
• Wikidata: Q82287718
• Mol file: 15286-19-8.mol

Synonyms:15286-19-8;Phosphonic acid, (4-methoxyphenyl)-, dimethyl ester;SCHEMBL10721682;DTXSID00463015;10.14272/OPDVSBXFRVFBFU-UHFFFAOYSA-N.1;doi:10.14272/OPDVSBXFRVFBFU-UHFFFAOYSA-N.1

Chemical Property of Phosphonic acid, (4-methoxyphenyl)-, dimethyl ester

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 216.05514589
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)P(=O)(OC)OC

Technology Process of Phosphonic acid, (4-methoxyphenyl)-, dimethyl ester

There total 18 articles about Phosphonic acid, (4-methoxyphenyl)-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-bromo-4-methoxy-benzene (104-92-7) + phosphorous acid trimethyl ester (121-45-9) → dimethyl (4-methoxyphenyl)phosphonate (15286-19-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In benzene; at 20 ℃; Irradiation;

DOI:10.1021/jo020671a

Reference yield: 90.0%

4-methoxybenzenediazonium tetrafluoroborate (459-64-3) + Dimethyl phosphite (868-85-9) → dimethyl (4-methoxyphenyl)phosphonate (15286-19-8)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; (triphenylphosphine)gold(I) chloride; In methanol; acetonitrile; at 20 ℃; for 4h; Irradiation; Inert atmosphere;

DOI:10.1039/c4sc03092c

Reference yield: 86.0%

1-bromo-4-methoxy-benzene (104-92-7) + Dimethyl phosphite (868-85-9) → dimethyl (4-methoxyphenyl)phosphonate (15286-19-8)

Guidance literature:

With (2,2'-bipyridine)nickel(II) dibromide; tetrabutylammomium bromide; triethylamine; In acetonitrile; at 20 ℃; for 3h; Electrochemical reaction;

DOI:10.1039/c8ob00500a

upstream raw materials:

p-Methoxy-phenyl-phosphonigsaeure-dimethylester

para-iodoanisole

phosphorous acid trimethyl ester

1-bromo-4-methoxy-benzene

Downstream raw materials:

(4-methoxyphenyl)phosphonic acid

(p-methoxyphenyl)dimethylphosphine oxide