DIETHYL 4-CYCLOHEXYL-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

Base Information

• Chemical Name: DIETHYL 4-CYCLOHEXYL-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
• CAS No.: 1539-59-9
• Molecular Formula: C19H29NO4
• Molecular Weight: 335.444
• Mol file: 1539-59-9.mol

Synonyms:diethyl 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;4-Cyclohexyl-3,5-dicarbethoxy-1,4-dihydro-lutidin;4-cyclohexyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester;1,4-dihydro-2,6-dimethyl-4-cyclohexylpyridine-3,5-dicarboxylic acid diethyl ester;

Chemical Property of DIETHYL 4-CYCLOHEXYL-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

Chemical Property:

• PSA: 64.63000
• LogP: 3.78910

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL 4-CYCLOHEXYL-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

There total 5 articles about DIETHYL 4-CYCLOHEXYL-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl acetoacetate (141-97-9) + cyclohexanecarbaldehyde (2043-61-0) → 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (1539-59-9)

Guidance literature:

With ammonium acetate; In 2,2,2-trifluoroethanol; at 70 ℃; for 3h;

DOI:10.1016/j.jfluchem.2009.03.014

Reference yield: 89.0%

Cyclohexyl iodide (626-62-0) + 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester (1149-24-2) → 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (1539-59-9)

Guidance literature:

With dimanganese decacarbonyl; In dichloromethane; at 20 ℃; for 12h; Solvent; Inert atmosphere; Irradiation; Schlenk technique;

DOI:10.1021/acs.orglett.1c01210

Reference yield: 86.0%

Cyclohexyl iodide (626-62-0) + diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1149-23-1) → 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (1539-59-9)

Guidance literature:

With dimanganese decacarbonyl; In dichloromethane; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere; Irradiation; Schlenk technique;

DOI:10.1021/acs.orglett.1c01210

upstream raw materials:

ethyl acetoacetate

cyclohexanecarbaldehyde

ethyl aminocrotonate

Cyclohexyl iodide

Downstream raw materials:

C₁₃H₁₇NO₄*HNO₂

trans-1-methoxy-4-(2-cyclohexylethenyl)benzene

cyclohexanecarboxylic acid phenethylamide

(Z)-β-(cyclohexylmethyl)styrene