201667-72-3

Upstream product

• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 5927-18-4 trimethyl phosphonoacetate 
• 5689-71-4 2-(4-methoxy-phenyl)-[1,3]dioxane 
• 123-11-5 4-methoxy-benzaldehyde 
• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 146986-42-7 ((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl) oxiran-2-yl)methanol 
• 242808-65-7 ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol 
• 292850-52-3 (2E)-5-(4-methoxybenzyloxy)-2-pentenoic acid 
• 62592-80-7 methyl trans-5-hydroxy-2-pentenoate 
• 158817-23-3 (2R,3R)-5-p-methoxybenzyloxy-3-methylpentane-1,2-diol 
• 1005776-31-7 (E)-ethyl-3-((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)acrylates 
• 1376666-11-3 (4R,5S,E)-ethyl-5-hydroxy-7-(4-methoxybenzyloxy)-4-methylhept-2-enoate 
• 1376666-13-5 C₂₂H₃₈O₄Si 
• 1376666-15-7 C₂₂H₃₆O₄Si 
• 1376666-17-9 C₂₆H₄₂O₅Si 
• 1376666-04-4 C₂₃H₂₅F₃O₆ 
• 794527-59-6 (2R,3S)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-oxirane-2-carbaldehyde 
• 1427556-29-3 (2S,3R)-5-[(4-methoxybenzyl)oxy]-2-methylpentane-1,3-diol 

Relevant academic research and scientific papers

Synthesis of the spiroketal core of integramycin

A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.

Synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin

We describe herein a short and efficient synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin. Notable features of this approach include a Sharpless asymmetric epoxidation followed by epoxide opening under Myashita's conditions to in

Stereodivergent approach to enantiopure hydroxyindolizidines through 1,3-dipolar cycloaddition of 3-hydroxypyrroline N-oxide derivatives

The (3S)-3-alkoxypyrroline N-oxides 7 and 27 were easily prepared from 1-malic acid and used as starting materials for enantiospecific syntheses of stereo differentiated polyhydro-xyindolizidines. Selection of the appropriate modality (inter or intramolec

Stereoselective approach to hydroxyindolizidines: Protection/deprotection of the nitrone functionality via cycloaddition/retrocycloaddition

(equation presented) The enantiomerically pure indolizidine (-)-21 has been synthesized starting from L-malic acid. The key intermediate 20 has been assembled through an intramolecular 1,3-dipolar cycloaddition of a nitrone generated in situ by retrocyclo

Application of the 2-azaallyl anion cycloaddition method to an enantioselective total synthesis of (+)-coccinine

A highly functionalized perhydroindole is formed by the intramolecular [π4s+π2s] cycloaddition of a 2-azaallyl anion with a vinyl sulfide [Eq. (a)]. This is the key step in the total synthesis of (+)-coccinine, the enantiomer of the Amaryllidaceae alkaloi

Synthetic studies on ciguatoxin [1]; construction of the spiro acetal part (C46-C55)

The spiro acetal part (C46-C55) of ciguatoxin was synthesized stereoselectively.