3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID

Base Information

• Chemical Name: 3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID
• CAS No.: 10538-48-4
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918990090
• Mol file: 10538-48-4.mol

Synonyms:2,3-DIMETHOXYHYDROCINNAMIC ACID;3-(2,3-DIMETHOXYPHENYL)PROPIONIC ACID;3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID;2,3-DiMethoxybenzenepropanoic Acid;2,3-DiMethoxybenzenepropionic Acid;2,3-DiMethoxy-β-phenylpropionic Acid;NSC 235796;β-(2,3-DiMethoxyphenyl)propionic Acid

Chemical Property of 3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 6.03E-05mmHg at 25°C
• Melting Point: 64-68 °C(lit.)
• Boiling Point: 331.9 °C at 760 mmHg
• PKA: 4.73±0.10(Predicted)
• Flash Point: 126.2 °C
• PSA: 55.76000
• Density: 1.159 g/cm³
• LogP: 1.72100
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

3-(2,3-Dimethoxyphenyl)propionic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-(2,3-Dimethoxyphenyl)propionic acid is a phenylalkylcarboxylic acid used in the synthesis of the 5-HT2c receptor agonists as biologically active compounds.

Technology Process of 3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID

There total 6 articles about 3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-2,3-dimethoxycinnamic acid (7345-82-6) → 2,3-dimethoxyhydrocinnamic acid (10538-48-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; at 35 - 40 ℃; under 2585.7 Torr;

DOI:10.1021/jm00391a007

Reference yield: 100.0%

2,3-dimethoxycinnamic acid (7461-60-1) → 2,3-dimethoxyhydrocinnamic acid (10538-48-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;

Reference yield:

2,3-dimethyoxybenzaldehyde (86-51-1) → 2,3-dimethoxyhydrocinnamic acid (10538-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 4percent piperidine / pyridine / Heating

2: 80 percent / H₂ / 5percent Pd/C / ethyl acetate / 40 °C / 2068.6 Torr

With hydrogen; piperidine; palladium on activated charcoal; In pyridine; ethyl acetate;

DOI:10.1021/jo00186a010

upstream raw materials:

2,3-dimethoxycinnamic acid

trans-2,3-dimethoxycinnamic acid

2,3-dimethyoxybenzaldehyde

2,3-dimethoxy-cis-cinnamic acid

Downstream raw materials:

6-methoxy-3-(3',4',5'-trimethoxyphenyl)-1H-inden-7-ol

Refernces

• 1、 Niu, Haichan,Strecker, Tracy E.,Gerberich, Jeni L.,Campbell, James W.,Saha, Debabrata,Mondal, Deboprosad,Hamel, Ernest,Chaplin, David J.,Mason, Ralph P.,Trawick, Mary Lynn,Pinney, Kevin G.. "Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization". . p. 5594 - 5615. Retrieved 2019/06/07.
• 2、 Herdman, Christine A.,Strecker, Tracy E.,Tanpure, Rajendra P.,Chen, Zhi,Winters, Alex,Gerberich, Jeni,Liu, Li,Hamel, Ernest,Mason, Ralph P.,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.. "Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization". supporting information. p. 2418 - 2427. Retrieved 2016/12/18.