3-(2,3-Dimethoxyphenyl)propan-1-ol

Base Information

• Chemical Name: 3-(2,3-Dimethoxyphenyl)propan-1-ol
• CAS No.: 103853-10-7
• Molecular Formula: C11H16 O3
• Molecular Weight: 196.246
• DSSTox Substance ID: DTXSID30548561
• Wikidata: Q82427305
• Mol file: 103853-10-7.mol

Synonyms:3-(2,3-dimethoxyphenyl)propan-1-ol;103853-10-7;Benzenepropanol,2,3-dimethoxy-;3-(2,3-DIMETHOXY-PHENYL)-PROPAN-1-OL;SCHEMBL985240;DTXSID30548561;UZYOQKCMPDEWAJ-UHFFFAOYSA-N;AKOS005217785;CS-0303124;EN300-1845731

Chemical Property of 3-(2,3-Dimethoxyphenyl)propan-1-ol

Chemical Property:

• Vapor Pressure: 0.000488mmHg at 25°C
• Refractive Index: 1.512
• Boiling Point: 300.8°C at 760 mmHg
• Flash Point: 135.7°C
• PSA: 38.69000
• Density: 1.064g/cm³
• LogP: 1.62870
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 196.109944368
• Heavy Atom Count: 14
• Complexity: 150

Purity/Quality:

97% ^*data from raw suppliers

3-(2,3-DIMETHOXY-PHENYL)-PROPAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)CCCO

Technology Process of 3-(2,3-Dimethoxyphenyl)propan-1-ol

There total 5 articles about 3-(2,3-Dimethoxyphenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-3-(2,3-dimethoxyphenyl)prop-2-en-1-ol (1137838-36-8) → 3-(2,3-dimethoxyphenyl)propan-1-ol (103853-10-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 1h;

DOI:10.1016/j.bmcl.2012.09.021 DOI:10.1016/j.bmcl.2012.09.021

Reference yield: 96.0%

(E)-ethyl 3-(2,3-dimethoxyphenyl)prop-2-enoate (79618-90-9) → 3-(2,3-dimethoxyphenyl)propan-1-ol (103853-10-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 3h;

DOI:10.1055/s-1997-4474

Reference yield:

trans-2,3-dimethoxycinnamic acid (7345-82-6) → 3-(2,3-dimethoxyphenyl)propan-1-ol (103853-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: LiAlH₄

With lithium aluminium tetrahydride; sulfuric acid;

DOI:10.1021/jo048557a

upstream raw materials:

(E)-ethyl 3-(2,3-dimethoxyphenyl)prop-2-enoate

2,3-dimethoxyhydrocinnamic acid

trans-2,3-dimethoxycinnamic acid

2,3-dimethyoxybenzaldehyde

Downstream raw materials:

dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

3-(2,3-dihydroxyphenyl)propylphosphonic acid

2-(3-benzyloxy-propyl)-N-(3,5-dichloro-pyridin-4-yl)-3,4-dimethoxy-benzamide

2-(3-benzyloxy-propyl)-3,4-dimethoxy-benzoic acid