1-Acetyl-2-methylcyclopentane

Base Information

• Chemical Name: 1-Acetyl-2-methylcyclopentane
• CAS No.: 1601-00-9
• Molecular Formula: C8H14O
• Molecular Weight: 126.199
• Hs Code.: 2914299000
• Mol file: 1601-00-9.mol

Synonyms:Ethanone, 1-(2-methylcyclopentyl)-;1-Acetyl-2-methyl-cyclopentan;1-(2-Methyl-cyclopentyl)-aethanon;Methyl-(2-methyl-cyclopentyl)-keton;1-(2-methyl-cyclopentyl)-ethanone;Methyl-2-methylcyclopentyl-keton;Methyl-(2-methylcyclopentyl)-keton;

Chemical Property of 1-Acetyl-2-methylcyclopentane

Chemical Property:

• Refractive Index: 1.4434
• Boiling Point: 170.5°C (estimate)
• PSA: 17.07000
• Density: 0.9222
• LogP: 2.01160

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Acetyl-2-methylcyclopentane

There total 19 articles about 1-Acetyl-2-methylcyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid pent-4-enyl ester (19300-54-0) → 1-(2-methyl-1-cyclopentyl)-ethanone (1601-00-9,3664-69-5,3664-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (4,5-dihydroIMES)Cl₂Ru=CH-o-OiPrC₆H₄ / CH₂Cl₂

2: (CuOTf)2*C₆H₆; 2-(diphenylphosphino)-phenyl-L-Tle-L-Tyr(OBut)-Bu / toluene / 12 h / 22 °C

With copper(I) trifluoromethanesulfonate benzene; 2-(diphenylphosphino)-phenyl-L-Tle-L-Tyr(OBut)-Bu; (4,5-dihydroIMES)Cl₂Ru=CH-o-OiPrC₆H₄; In dichloromethane; toluene;

DOI:10.1021/ja0122849

Reference yield:

2-methylcyclopentane carboxylic acid (5454-78-4) + methyllithium (917-54-4) → methyl 2-methylcyclopentyl ketone (1601-00-9)

Guidance literature:

In diethyl ether; at -20 - 20 ℃; for 18.5h; Inert atmosphere;

Reference yield:

1-tosyloxy-4-heptene-6-one + dimethyl zinc(II) (544-97-8) → (-)-1-(2-methyl-1-cyclopentyl)-ethanone (403641-43-0) + 1-(2-methyl-1-cyclopentyl)-ethanone (1601-00-9,3664-69-5,3664-70-8)

Guidance literature:

With copper(I) trifluoromethanesulfonate benzene; 2-(diphenylphosphino)-phenyl-L-Tle-L-Tyr(OBut)-Bu; In toluene; at 22 ℃; for 12h;

DOI:10.1021/ja0122849

upstream raw materials:

1-acetyl-2-methyl-cyclopentanecarboxylic acid ethyl ester

cyclohexane

acetyl chloride

aluminium trichloride

Downstream raw materials:

2-ethyl-1-methylcyclopentane

1ref-Carbamoyl-1t,2c-dimethyl-cyclopentan

Refernces

• 1、 Tabushi et al.. "". . p. 4247. Retrieved 1968.
• 2、 -. "COMPOUNDS USEFUL AS MODULATORS OF TRPM8". Paragraph 0601. . Retrieved 2016/03/29.
• 3、 Mizutani, Hirotake,Degrado, Sylvia J.,Hoveyda, Amir H.. "Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones". . p. 779 - 781. Retrieved 2007/10/03.