2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE

Base Information

• Chemical Name: 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE
• CAS No.: 161117-67-5
• Molecular Formula: C₁₄H₂₁NO₃S
• Molecular Weight: 283.392
• Hs Code.: 2935009090
• Mol file: 161117-67-5.mol

Synonyms:2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE;2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROLO-3-ACETIC ACID;

Chemical Property of 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE

Chemical Property:

• Vapor Pressure: 2.67E-08mmHg at 25°C
• Melting Point: 159-161 °C
• Boiling Point: 450.3oC at 760 mmHg
• PKA: 10.63±0.40(Predicted)
• Flash Point: 226.1oC
• PSA: 77.77000
• Density: 1.163g/cm3
• LogP: 4.14390

Purity/Quality:

98%Min ^*data from raw suppliers

2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE

There total 2 articles about 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride (112160-39-1) → 2,2,5,7,8-pentamethylchroman-6-sulfonamide (161117-67-5)

Guidance literature:

With ammonia; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1055/s-2007-983706

Reference yield:

2,2,5,7,8-pentamethyl-chromane (55646-01-0) → 2,2,5,7,8-pentamethylchroman-6-sulfonamide (161117-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonuc acid / CH₂Cl₂ / 3.5 h / 0 - 20 °C

2: 28.1 g / ammonia / CH₂Cl₂ / 3 h / 0 °C

With chlorosulfonic acid; ammonia; In dichloromethane;

DOI:10.1021/ol0498141

Reference yield:

2,2,5,7,8-pentamethylchroman-6-sulfonamide (161117-67-5) → N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-allyl-N''-(o-methoxyphenyl)guanidine (947748-66-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KOH / benzene / 24 h / Heating

1.2: 75 percent / COCl₂ / toluene / 0 - 20 °C

2.1: 81 percent / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 99 percent / EDCI*HCl / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; benzene;

DOI:10.1055/s-2007-983706

upstream raw materials:

2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride

2,2,5,7,8-pentamethyl-chromane

Downstream raw materials:

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzylthiourea

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(p-nitrophenyl)thiourea

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine