N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

Base Information

Chemical Name:N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine
CAS No.:947748-61-0
Molecular Formula:C₂₈H₃₉N₃O₄S
Molecular Weight:513.701
Hs Code.:

Synonyms:N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

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Technology Process of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

There total 4 articles about N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 947748-47-2
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea

: 622-33-3
N-benzyloxyamine

: 947748-61-0
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1055/s-2007-983706

Reference yield:

: 773147-11-8
(2,2,5,7,8-pentamethylchroman-6-sulfonyl)isothiocyanate

: 947748-61-0
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / CH₂Cl₂ / 0.5 h / 20 °C

2: 74 percent / EDCI*HCl / CH₂Cl₂ / 0.5 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1055/s-2007-983706

Reference yield:

: 112160-39-1
2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride

: 947748-61-0
N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / NH₃ / CH₂Cl₂ / 0.33 h / 0 °C

2.1: KOH / benzene / 24 h / Heating

2.2: 75 percent / COCl₂ / toluene / 0 - 20 °C

3.1: 94 percent / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 74 percent / EDCI*HCl / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; benzene;
DOI:10.1055/s-2007-983706