N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea

Base Information

• Chemical Name: N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea
• CAS No.: 947748-55-2
• Molecular Formula: C₂₂H₂₈N₂O₄S₂
• Molecular Weight: 448.607
• Mol file: 947748-55-2.mol

Synonyms:N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea

Chemical Property of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea

There total 3 articles about N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2,2,5,7,8-pentamethylchroman-6-sulfonyl)isothiocyanate (773147-11-8) + 2-methoxy-phenylamine (90-04-0) → N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea (947748-55-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1055/s-2007-983706

Reference yield:

2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride (112160-39-1) → N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea (947748-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / NH₃ / CH₂Cl₂ / 0.33 h / 0 °C

2.1: KOH / benzene / 24 h / Heating

2.2: 75 percent / COCl₂ / toluene / 0 - 20 °C

3.1: 81 percent / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; ammonia; In dichloromethane; benzene;

DOI:10.1055/s-2007-983706

Reference yield:

2,2,5,7,8-pentamethylchroman-6-sulfonamide (161117-67-5) → N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea (947748-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KOH / benzene / 24 h / Heating

1.2: 75 percent / COCl₂ / toluene / 0 - 20 °C

2.1: 81 percent / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; In dichloromethane; benzene;

DOI:10.1055/s-2007-983706

upstream raw materials:

(2,2,5,7,8-pentamethylchroman-6-sulfonyl)isothiocyanate

2-methoxy-phenylamine

2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride

2,2,5,7,8-pentamethylchroman-6-sulfonamide

Downstream raw materials:

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-allyl-N''-(o-methoxyphenyl)guanidine

C₅₇H₆₆N₆O₈S₂