Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran

Base Information

• Chemical Name: Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran
• CAS No.: 16408-83-6
• Molecular Formula: C7H11F3O2
• Molecular Weight: 184.158
• Mol file: 16408-83-6.mol

Synonyms:2-(2,2,2-trifluoroethoxy)tetrahydropyran;2-<2,2,2-Trifluor-aethoxy>-tetrahydropyran;2-(2',2',2'-trifluoroethoxy)tetrahydropyran;2-(2,2,2-trifluoro-ethoxy)-tetrahydro-pyran;2-<2,2,2-Trifluor-aethoxy>-tetrahydro-pyran;

Chemical Property of Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran

Chemical Property:

• Boiling Point: 138 - 141 °C (760 mmHg)
• PSA: 18.46000
• LogP: 2.09190

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran

There total 2 articles about Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3,4-dihydro-2H-pyran (110-87-2) + 2,2,2-trifluoroethanol (75-89-8) → tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran (16408-83-6)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; Ambient temperature;

DOI:10.1055/s-1993-26015

Reference yield:

→ tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran (16408-83-6)

Guidance literature:

Aus 2,2,2-Trifluor-aethanol mit 3,4-Dihydro-pyran unter Zusatz von wenig Salzsaeure;

DOI:10.1139/v67-408

Reference yield:

tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran (16408-83-6) + bis(diethylamino)chlorophosphine (685-83-6) + benzaldehyde (100-52-7) → C22H35F2N2O3P

Guidance literature:

tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 1h; Inert atmosphere;

bis(diethylamino)chlorophosphine; Further stages;

DOI:10.1055/a-1578-2848

upstream raw materials:

3,4-dihydro-2H-pyran

2,2,2-trifluoroethanol