4-hydroxy-3-propionyl-2H-chromen-2-one

Base Information

• Chemical Name: 4-hydroxy-3-propionyl-2H-chromen-2-one
• CAS No.: 4139-73-5
• Molecular Formula: C12H10O4
• Molecular Weight: 218.2054
• Hs Code.: 2932209090
• Mol file: 4139-73-5.mol

Synonyms:4-hydroxy-3-propanoyl-2H-1-benzopyran-2-one;3-Propanoyl-4-hydroxycoumarin;4-hydroxy-3-propionylcoumarin;2-hydroxy-3-propanoylchromen-4-one;4-Hydroxy-3-propionyl-2H-chromen-2-one;4-hydroxy-3-propionyl-chromen-2-one;

Chemical Property of 4-hydroxy-3-propionyl-2H-chromen-2-one

Chemical Property:

• Vapor Pressure: 1.28E-05mmHg at 25°C
• Melting Point: 123 °C
• Boiling Point: 353.9°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 138.1°C
• PSA: 67.51000
• Density: 1.382g/cm³
• LogP: 2.09130

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxy-3-propionyl-2H-chromen-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-3-propionyl-2H-chromen-2-one

There total 5 articles about 4-hydroxy-3-propionyl-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + propionic acid (802294-64-0,79-09-4) → 4-hydroxy-3-propanoyl-2H-1-benzopyran-2-one (4139-73-5)

Guidance literature:

With trichlorophosphate; for 0.75h; Reflux;

DOI:10.1021/acs.jmedchem.0c01062

Reference yield: 24.0%

Methyl 3-(2-hydroxy-phenyl)-3-oxopropanoate (20349-86-4) + propionic acid anhydride (123-62-6) → 4-hydroxy-3-propanoyl-2H-1-benzopyran-2-one (4139-73-5) + methyl 2-ethyl-4-oxo-4H-1-benzopyran-3-carboxylate (129410-02-2)

Guidance literature:

With potassium carbonate; In toluene; a) 80 deg C, b) 125-130 deg C, 3 h;

DOI:10.1016/S0040-4020(01)88394-0

Reference yield:

4-propionyloxy-coumarin (36953-85-2) → 4-hydroxy-3-propanoyl-2H-1-benzopyran-2-one (4139-73-5)

Guidance literature:

With potassium cyanide; triethylamine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/S0040-4039(03)00012-1

upstream raw materials:

Methyl 3-(2-hydroxy-phenyl)-3-oxopropanoate

propionic acid anhydride

4-propionyloxy-coumarin

4-hydroxy[1]benzopyran-2-one

Downstream raw materials:

(3-Ethyl-5-hydroxy-1-phenyl-1H-pyrazol-4-yl)-(2-hydroxy-phenyl)-methanone

3-Ethyl-1-phenyl-1H-chromeno[2,3-c]pyrazol-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 4139-73-5 4-hydroxy-3-propionyl-2H-chromen-2-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send