4-(2,4-Dichlorophenoxy)phenol

Base Information

• Chemical Name: 4-(2,4-Dichlorophenoxy)phenol
• CAS No.: 40843-73-0
• Molecular Formula: C12H8Cl2O2
• Molecular Weight: 255.1
• Hs Code.: 2909500000
• European Community (EC) Number: 255-106-1
• UNII: 4DWA4SN6HT
• DSSTox Substance ID: DTXSID3068259
• Nikkaji Number: J294.770F
• Wikidata: Q72467239
• ChEMBL ID: CHEMBL4290691
• Mol file: 40843-73-0.mol

Synonyms:4-(2,4-Dichlorophenoxy)phenol;40843-73-0;Phenol, 4-(2,4-dichlorophenoxy)-;P-(2,4-DICHLOROPHENOXY)PHENOL;EINECS 255-106-1;4DWA4SN6HT;4-(2,4'-Dichlorophenxy)phenol;4-(2',4'-dichlorophenoxy)-phenol;4-(2',4'-DICHLOROPHENOXY)PHENOL;UNII-4DWA4SN6HT;SCHEMBL3469104;CHEMBL4290691;DTXSID3068259;4-(2,4-dichlorophenoxy)-phenol;MFCD08446912;AKOS002678553;BS-52302;4-(2,4-Dichlorophenoxy)phenol, AldrichCPR;CS-0000190;A856644;W-109226;D-MYO-INOSITOL1,4,5-TRISPHOSPHATEHEXASODIUMSALT

Chemical Property of 4-(2,4-Dichlorophenoxy)phenol

Chemical Property:

• Vapor Pressure: 1.69E-05mmHg at 25°C
• Refractive Index: 1.623
• Boiling Point: 354°C at 760mmHg
• Flash Point: 167.9°C
• PSA: 29.46000
• Density: 1.398g/cm³
• LogP: 4.49130
• Storage Temp.: 2-8°C
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 253.9901349
• Heavy Atom Count: 16
• Complexity: 217

Purity/Quality:

99%, ^*data from raw suppliers

4-(2,4-Dichlorophenoxy)phenol Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1O)OC2=C(C=C(C=C2)Cl)Cl

Technology Process of 4-(2,4-Dichlorophenoxy)phenol

There total 4 articles about 4-(2,4-Dichlorophenoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H7Cl2N2O(1+)*BF4(1-) → 4-(2',4'-dichlorophenoxy)-phenol (40843-73-0)

Guidance literature:

Multistep reaction; (i) Ac₂O, (ii) aq. NaOH, MeOH;

Reference yield:

1-bromo-2,4-dichlorobenzene (1193-72-2) + phenol (108-95-2,27073-41-2) → 4-(2',4'-dichlorophenoxy)-phenol (40843-73-0)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1071/CH9951503

Reference yield:

2,4-dichloro-4'-aminodiphenyl ether (14861-17-7) → 4-(2',4'-dichlorophenoxy)-phenol (40843-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. HCl, AcOH, (ii) NaNO₂, aq. HBF₄

2: (i) Ac₂O, (ii) aq. NaOH, MeOH

upstream raw materials:

1-bromo-2,4-dichlorobenzene

phenol

2,4-dichloro-4'-aminodiphenyl ether

Downstream raw materials:

Ethyl 4-[4(2,4-dichlorophenoxy)phenoxy]⁽²⁾-pentenoate

2-[4-(2,4-Dichloro-phenoxy)-phenoxy]-propionic acid 2-methoxy-ethyl ester

Propionic acid 4-(2,4-dichloro-phenoxy)-phenyl ester

[4-(2,4-Dichloro-phenoxy)-phenoxy]-phenyl-acetic acid

Refernces

• 1、 -. "Quinoline derivative as well as preparation method and application thereof (by machine translation)". Paragraph 0261; 0263-0267. . Retrieved 2019/11/28.
• 2、 -. "4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture". . . Retrieved 2008/06/13.