D-Valine, 3-methyl-, methyl ester, hydrochloride

Base Information

• Chemical Name: D-Valine, 3-methyl-, methyl ester, hydrochloride
• CAS No.: 167223-43-0
• Molecular Formula: C7H15NO2.ClH
• Molecular Weight: 181.66000
• Hs Code.: 2922500090
• Mol file: 167223-43-0.mol

Synonyms:D-Valine, 3-methyl-, methyl ester, hydrochloride (1:1);D-Valine, 3-methyl-, methyl ester, hydrochloride (9CI);

Chemical Property of D-Valine, 3-methyl-, methyl ester, hydrochloride

Chemical Property:

• Melting Point: 169-173°C
• PSA: 52.32000
• LogP: 2.03510
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

D-tert-Leucine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: D-tert-Leucine Methyl Ester Hydrochloride could be useful for preparing peptides for the treatment of inflammatory diseases.

Technology Process of D-Valine, 3-methyl-, methyl ester, hydrochloride

There total 10 articles about D-Valine, 3-methyl-, methyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + L-tert-Leucine (20859-02-3) → L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1002/anie.201902513

Reference yield: 80.0%

methanol (67-56-1) + 2-amino-3,3-dimethylbutanoic acid (33105-81-6) → H-D,L-TleOMe·HCl (22146-61-8,167223-43-0)

Guidance literature:

With thionyl chloride; at 0 - 70 ℃; for 16h;

DOI:10.1021/jacs.1c11266

Reference yield: 76.0%

methanol (67-56-1) + N-tert-butyloxycarbonyl-L-tert-leucine (62965-35-9) → L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0)

Guidance literature:

With thionyl chloride; at 0 - 80 ℃; for 8h; Inert atmosphere;

upstream raw materials:

methanol

2-amino-3,3-dimethylbutanoic acid

L-tert-Leucine

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

Downstream raw materials:

N-phthaloyl-(S)-tert-leucine methyl ester

methyl (1aR,5S,8S,10R,18E,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylate

methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3,3-dimethyl]butanoate

C₂₀H₂₀ClF₃N₂O₃