2-Chloro-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]acetamide

Base Information

• Chemical Name: 2-Chloro-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]acetamide
• CAS No.: 18199-99-0
• Molecular Formula: C11H10ClN3O2S
• Molecular Weight: 283.738
• Mol file: 18199-99-0.mol

Synonyms:5-(4-Methoxyphenyl)-2-chloracetamino-1,3,4-thiadiazol;2-chloroacetamido-5-(4-methoxyphenyl)-1,3,4-thiadiazole;2-Chloro-N-[5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-acetamide;

Chemical Property of 2-Chloro-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]acetamide

Chemical Property:

• Melting Point: 231 - 232 °C
• PSA: 92.35000
• LogP: 2.46400

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]acetamide

There total 5 articles about 2-Chloro-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-ylamine (1014-25-1) + chloroacetyl chloride (79-04-9) → 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide (18199-99-0)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 4.16667h;

Reference yield:

4-methoxybenzoic acid (100-09-4) → 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide (18199-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Reflux

2: pyridine / benzene / Reflux

With pyridine; trichlorophosphate; In benzene;

DOI:10.5012/bkcs.2011.32.3.1011

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide (18199-99-0)

Guidance literature:

Multi-step reaction with 3 steps

1: water / Heating

2: iron(III) chloride / water / 0.75 h / 80 - 90 °C

3: benzene / Reflux

With iron(III) chloride; In water; benzene;

upstream raw materials:

5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-ylamine

chloroacetyl chloride

C₉H₁₁N₃O₂S

4-methoxy-benzaldehyde

Downstream raw materials:

2-[{5-(4-methoxyphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one

C₁₅H₁₈N₄O₃S

C₁₉H₂₈N₄O₂S

C₁₉H₂₈N₄O₂S