2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)-

Base Information

Chemical Name:2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)-
CAS No.:183504-77-0
Molecular Formula:C11H11ClO2
Molecular Weight:210.66
Hs Code.:
DSSTox Substance ID:DTXSID30441740
Nikkaji Number:J1.226.173J
Wikidata:Q82258659

Synonyms:2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)-;183504-77-0;DTXSID30441740;4beta-(4-Chlorophenyl)tetrahydro-2H-pyran-2-one

Suppliers and Price of 2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:210.0447573
Heavy Atom Count:14
Complexity:209

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC(=O)CC1C2=CC=C(C=C2)Cl
Isomeric SMILES:C1COC(=O)C[C@H]1C2=CC=C(C=C2)Cl

Technology Process of 2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)-

There total 5 articles about 2H-Pyran-2-one, 4-(4-chlorophenyl)tetrahydro-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3393-45-1
5,6-dihydro-pyran-2-one

: 1679-18-1
4-Chlorophenylboronic acid

: 183504-77-0
4-(4-chlorophenyl)tetrahydro-2H-pyran-2-one

Guidance literature:: With (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); bis(ethylene)rhodium acetylacetonate; In 1,4-dioxane; water; at 100 ℃; for 3h;
DOI:10.1016/S0957-4166(99)00417-6

Reference yield:

: (S)-3-(4-Chloro-phenyl)-5-hydroxy-pentanoic acid

: 183504-77-0
4-(4-chlorophenyl)tetrahydro-2H-pyran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 3.5h; Yield given; Heating;
DOI:10.1021/jo961096b

Reference yield:

: 101104-10-3
diethyl 3-(4-chlorophenyl)glutarate

: 183504-77-0
4-(4-chlorophenyl)tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / α-chymotrypsin, aq. KCl / 120 h / Ambient temperature; pH 7.8

2: LiBH₄ / 1,2-dimethoxy-ethane; methanol / 1 h / Heating

3: p-toluenesulfonic acid / toluene / 3.5 h / Heating

With lithium borohydride; potassium chloride; toluene-4-sulfonic acid; α-chymotrypsin; In methanol; 1,2-dimethoxyethane; toluene;
DOI:10.1021/jo961096b