Propanamide, N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-

Base Information

• Chemical Name: Propanamide, N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-
• CAS No.: 1838-67-1
• Molecular Formula: C₂₃H₃₀N₂O
• Molecular Weight: 350.504
• Mol file: 1838-67-1.mol

Synonyms:

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Chemical Property of Propanamide, N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanamide, N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-

There total 4 articles about Propanamide, N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide (1838-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

p-toluidine (106-49-0,12221-03-3) → N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide (1838-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

1-(β-Phenylethyl)-4-(p-toluidino)piperidine (28456-20-4) + propionic acid anhydride (123-62-6) → N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide (1838-67-1)

Guidance literature:

In toluene; for 3h; Heating;

DOI:10.1002/jhet.5570260329

upstream raw materials:

1-(β-Phenylethyl)-4-(p-toluidino)piperidine

propionic acid anhydride

1-(2-phenylethyl)-4-piperidinone

p-toluidine