L-Leucinamide, L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-L-seryl-L-lys yl-L-phenylalanyl-L-leucylglycyl-L-arginyl-L-isoleucyl-

Base Information

• Chemical Name: L-Leucinamide, L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-L-seryl-L-lys yl-L-phenylalanyl-L-leucylglycyl-L-arginyl-L-isoleucyl-
• CAS No.: 188713-81-7
• Molecular Formula: C₈₃H₁₂₂N₂₀O₁₅
• Molecular Weight: 1640.01
• Mol file: 188713-81-7.mol

Synonyms:

Chemical Property of L-Leucinamide, L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-L-seryl-L-lys yl-L-phenylalanyl-L-leucylglycyl-L-arginyl-L-isoleucyl-

Chemical Property:

Purity/Quality:

>97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Leucinamide, L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-L-seryl-L-lys yl-L-phenylalanyl-L-leucylglycyl-L-arginyl-L-isoleucyl-

There total 3 articles about L-Leucinamide, L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-L-seryl-L-lys yl-L-phenylalanyl-L-leucylglycyl-L-arginyl-L-isoleucyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C144H187N20O22PolS → temporin-1 TL (188713-81-7)

Guidance literature:

C₁₄₄H₁₈₇N₂₀O₂₂PolS; With piperidine; solid phase reaction;

With chlorotriisopropylsilane; trifluoroacetic acid; In water; solid phase reaction;

DOI:10.1021/ja102167m

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-Ile-OH (71989-23-6,251316-98-0) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + Fmoc-L-Gln(Trt)-OH (132327-80-1,200623-62-7) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → temporin-1 TL (188713-81-7)

Guidance literature:

Fmoc-Leu-OH; With C₂₂H₂₂NO₃Pol; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Inert atmosphere; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; for 0.416667h; Inert atmosphere; solid phase reaction;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; Fmoc-Leu-OH; N-Fmoc L-Phe; Fmoc-Ser(tBu)-OH; Fmoc-Ile-OH; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-L-Gln(Trt)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

DOI:10.1021/jm1012853

Reference yield:

C94H127BrN20O20 → temporin-1 TL (188713-81-7)

Guidance literature:

for 0.0833333h; UV-irradiation;

DOI:10.1021/ja102167m

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH

Fmoc-Leu-OH

N-Fmoc L-Phe